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Butyrophilin and butyrophilin-like proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Butyrophilin (BTN) proteins modulate T cell responses to antigen presentation by MHC molecules and cognate αβ T cell receptor (TCR) engagement. Some BTNs mediate interactions between antigen-presenting cells and conventional αβ T cells (as immune checkpoints), and others regulate activity of specific γδ T cell subsets in the maintenance of barrier integrity at mucosal surfaces for example- reviewed in [1].


butyrophilin like 3 Show summary » More detailed page

butyrophilin like 8 Show summary » More detailed page

butyrophilin subfamily 3 member A1 Show summary » More detailed page


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How to cite this family page

Database page citation:

Butyrophilin and butyrophilin-like proteins. Accessed on 25/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.