nucleotide binding oligomerization domain containing 1 | NOD-like receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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nucleotide binding oligomerization domain containing 1

target has curated data in GtoImmuPdb

Target id: 1762

Nomenclature: nucleotide binding oligomerization domain containing 1

Abbreviated Name: NOD1

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 953 7p14.3 NOD1 nucleotide binding oligomerization domain containing 1
Mouse - 953 6 27.22 cM Nod1 nucleotide-binding oligomerization domain containing 1
Rat - - 4q24 Nod1 nucleotide-binding oligomerization domain containing 1
Previous and Unofficial Names
CARD4 | caspase recruitment domain family, member 4 | CLR7.1 | NLRC1 | NLR family, CARD domain containing 1 | nucleotide-binding oligomerization domain containing 1 | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1 (NLRC1)
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ML130 Hs Inhibition 6.3 pIC50 1
pIC50 6.3 (IC50 5.6x10-7 M) [1]
Immunopharmacology Comments
NOD1 is an intracellular pattern recognition receptor that initiates an immune response to bacterial molecules containing a D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety.

Mutations in NOD proteins are implicated in various inflammatory diseases associated with aberrant NF-κB activity; NF-κB being a major component of the signaling pathways involved in apoptosis, inflammation, and the immune response.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0006954 inflammatory response TAS
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
click arrow to show/hide IEA associations
GO:0045087 innate immune response IEA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 5 GO processes
GO:0042228 interleukin-8 biosynthetic process IDA
GO:0070498 interleukin-1-mediated signaling pathway TAS
click arrow to show/hide IEA associations
GO:0032731 positive regulation of interleukin-1 beta production IEA
GO:0032755 positive regulation of interleukin-6 production IEA
GO:0032760 positive regulation of tumor necrosis factor production IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
Immuno Disease Associations
Disease Name:  Behcet syndrome
Disease Synonyms:  no synonynms
Comment:  Genetic variations in NOD1 are associated with Behcet's disease in a Chinese Han population, and confer disease susceptibility.
Disease X-refs:  Disease Ontology: DOID:13241
OMIM: 109650
Orphanet: ORPHA117
References:  2
Physiological Functions Comments
Pro-inflammatory, involved in autophagy.

References

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1. Khan PM, Correa RG, Divilianska DB, Peddibhotla S, Sessions EH, Magnuson G, Brown B, Suyama E, Yuan H, Mangravita-Nov A et al.. (2011) Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation. ACS Med Chem Lett., 2: 780-785. [PMID:22003428]

2. Li L, Yu H, Jiang Y, Deng B, Bai L, Kijlstra A, Yang P. (2016) Genetic Variations of NLR family genes in Behcet's Disease. Sci Rep, 6: 20098. [PMID:26833430]

Contributors

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