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NLRP10

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1777

Nomenclature: NLRP10

Family: NOD-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 655 11p15.4 NLRP10 NLR family pyrin domain containing 10
Mouse - 673 7 E3 Nlrp10 NLR family, pyrin domain containing 10
Rat - - 1q33 Nlrp10 NLR family, pyrin domain containing 10
Previous and Unofficial Names Click here for help
NALP10 | NOD8 | PAN5 | Pynod | NACHT, leucine rich repeat and PYD containing 10 | NLR family, pyrin domain containing 10 | CLR11.1 | NLR family
Database Links Click here for help
Alphafold
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Immunopharmacology Comments
NLRP10 is an intracellular pattern recognition receptor (PRR) that has apoptotic and anti-inflammatory functions [1]. Unlike other other NOD-like receptors, NLRP10 is missing the characteristic leucine-rich repeat domain.
Physiological Functions Comments
Involved in antigen-presenting cell migration, T-Cell priming and NOD1 signalling enhancement.

References

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1. Imamura R, Wang Y, Kinoshita T, Suzuki M, Noda T, Sagara J, Taniguchi S, Okamoto H, Suda T. (2010) Anti-inflammatory activity of PYNOD and its mechanism in humans and mice. J Immunol, 184 (10): 5874-84. [PMID:20393137]

Contributors

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