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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1777

Nomenclature: NLRP10

Family: NOD-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 655 11p15.4 NLRP10 NLR family pyrin domain containing 10
Mouse - 673 7 E3 Nlrp10 NLR family, pyrin domain containing 10
Rat - - 1q33 Nlrp10 NLR family, pyrin domain containing 10
Previous and Unofficial Names Click here for help
NALP10 | NOD8 | PAN5 | Pynod | NACHT, leucine rich repeat and PYD containing 10 | NLR family, pyrin domain containing 10 | CLR11.1 | NLR family
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
NLRP10 is an intracellular pattern recognition receptor (PRR) that has apoptotic and anti-inflammatory functions [1]. Unlike other other NOD-like receptors, NLRP10 is missing the characteristic leucine-rich repeat domain.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Physiological Functions Comments
Involved in antigen-presenting cell migration, T-Cell priming and NOD1 signalling enhancement.


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1. Imamura R, Wang Y, Kinoshita T, Suzuki M, Noda T, Sagara J, Taniguchi S, Okamoto H, Suda T. (2010) Anti-inflammatory activity of PYNOD and its mechanism in humans and mice. J Immunol, 184 (10): 5874-84. [PMID:20393137]


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