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fms related receptor tyrosine kinase 3

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1807

Nomenclature: fms related receptor tyrosine kinase 3

Abbreviated Name: FLT3

Family: Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 993 13q12.2 FLT3 fms related receptor tyrosine kinase 3
Mouse 1 1000 5 G3 Flt3 FMS-like tyrosine kinase 3
Rat - 1000 12p11 Flt3 Fms related receptor tyrosine kinase 3
Previous and Unofficial Names Click here for help
CD135 | Fetal liver kinase 2 | FL cytokine receptor | FLK2 | FMS-like tyrosine kinase 3 | fms-related tyrosine kinase 3 | fms related tyrosine kinase 3 | STK1
Database Links Click here for help
Alphafold P36888 (Hs), Q00342 (Mm)
BRENDA 2.7.10.1
CATH/Gene3D 2.60.40.10
ChEMBL Target CHEMBL1974 (Hs), CHEMBL2034796 (Mm)
DrugBank Target P36888 (Hs)
Ensembl Gene ENSG00000122025 (Hs), ENSMUSG00000042817 (Mm), ENSRNOG00000054764 (Rn)
Entrez Gene 2322 (Hs), 14255 (Mm), 140635 (Rn)
Human Protein Atlas ENSG00000122025 (Hs)
KEGG Enzyme 2.7.10.1
KEGG Gene hsa:2322 (Hs), mmu:14255 (Mm), rno:140635 (Rn)
OMIM 136351 (Hs)
Orphanet ORPHA138366 (Hs)
Pharos P36888 (Hs)
RefSeq Nucleotide NM_004119 (Hs), NM_010229 (Mm), NM_001100822 (Rn)
RefSeq Protein NP_004110 (Hs), NP_034359 (Mm), NP_001094292 (Rn)
UniProtKB P36888 (Hs), Q00342 (Mm)
Wikipedia FLT3 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of a human Flt3 ligand-receptor ternary complex
PDB Id:  3QS7
Resolution:  4.3Å
Species:  Human
References:  64
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of FLT3
PDB Id:  1RJB
Resolution:  2.1Å
Species:  Human
References:  25
Enzyme Reaction Click here for help
EC Number: 2.7.10.1
Natural/Endogenous Ligands Click here for help
Fms-related tyrosine kinase 3 ligand {Sp: Human}

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
AC710 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 9.3 pKd 40
⤷ pKd 9.3 (Kd 5x10-10 M) [40]
linifanib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 9.2 pKd 13
⤷ pKd 9.2 (Kd 6.3x10-10 M) [13]
dovitinib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 9.2 pKd 13
⤷ pKd 9.2 (Kd 6.4x10-10 M) [13]
crenolanib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition 9.1 pKd 27
⤷ pKd 9.1 (Kd 7.4x10-10 M) [27]
AST-487 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 9.1 pKd 13
⤷ pKd 9.1 (Kd 7.9x10-10 M) [13]
quizartinib Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.8 – 8.9 pKd 10,13
⤷ pKd 8.8 – 8.9 (Kd 1.6x10-9 – 1.3x10-9 M) [10,13]
compound 6li [Chan et al., 2022] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.6 pKd 9
⤷ pKd 8.6 (Kd 2.5x10-9 M) [9]
tandutinib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.5 pKd 13
⤷ pKd 8.5 (Kd 3x10-9 M) [13]
compound 5e [PMID: 28580438] Small molecule or natural product Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 8.4 pKd 28
⤷ pKd 8.4 (Kd 3.6x10-9 M) [28]
Description: Measured using the Z′-LYTE Kinase Assay Kit and wild type FLT3.
lestaurtinib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition 8.1 pKd 13
⤷ pKd 8.1 (Kd 8.5x10-9 M) [13]
midostaurin Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition 8.0 pKd 13
⤷ pKd 8.0 (Kd 1.1x10-8 M) [13]
RG-1530 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.0 pKd 62
⤷ pKd 8.0 (Kd 1.1x10-8 M) [62]
KW-2449 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 7.8 pKd 13
⤷ pKd 7.8 (Kd 1.5x10-8 M) [13]
mobinitinib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.5 – 7.6 pKd 74
⤷ pKd 7.6 (Kd 2.6x10-8 M) [74]
Description: Affinity for WT FLT3
pKd 7.5 (Kd 3.4x10-8 M) [74]
Description: Affinity for FLT3-ITD mutant
belizatinib Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.4 pKd 39
⤷ pKd 7.4 (Kd 4.2x10-8 M) [39]
Description: Binding affinity in vitro.
UNC4203 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 7.8 pKi 83
⤷ pKi 7.8 (Ki 1.614x10-8 M) [83]
AST-487 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 6.9 pKi 69
⤷ pKi 6.9 (Ki 1.2x10-7 M) [69]
Description: Inhibition of wild type FLT3
nefextinib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.5 – 9.7 pIC50 75
⤷ pIC50 9.7 (IC50 2x10-10 M) [75]
Description: Inhibitor potency for FLT3 D835Y mutant
pIC50 9.6 (IC50 2.8x10-10 M) [75]
Description: Inhibition potency for WT FLT3
pIC50 9.5 (IC50 3.4x10-10 M) [75]
Description: Inhibitor potency for FLT3-ITD fusion
gilteritinib Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition ~9.5 pIC50 37
⤷ pIC50 ~9.5 (IC50 ~3x10-10 M) [37]
denfivontinib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 9.4 pIC50 36
⤷ pIC50 9.4 (IC50 4x10-10 M) [36]
Gö 6976 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 9.1 pIC50 79
⤷ pIC50 9.1 (IC50 7x10-10 M) [79]
Description: Inhibitory activity against recombinant FLT3 in an in vitro kinase assay.
TTT-3002 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.1 pIC50 42
⤷ pIC50 9.1 (IC50 7.2x10-10 M) [42]
Description: Inhibition of FLT3 phosphorylation in Molm14 human leukemia cells that carry the FLT3/ITD activation mutation
compound 8i [PMID: 22765894] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.1 pIC50 80
⤷ pIC50 9.1 (IC50 8x10-10 M) [80]
compound 8h [PMID: 22765894] Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 9.1 pIC50 32
⤷ pIC50 9.1 (IC50 8.5x10-10 M) [32]
dorsomorphin Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition >9.0 pIC50 43
⤷ pIC50 >9.0 (IC50 <1x10-9 M) [43]
Description: Assayed using AMPK heterotrimeric complex containing α2, β1, γ1 subunits
RGB-286638 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.0 pIC50 11
⤷ pIC50 9.0 (IC50 1x10-9 M) [11]
ilorasertib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.0 pIC50 21
⤷ pIC50 9.0 (IC50 1x10-9 M) [21]
Description: Measuring inhibition of kinase activity in a biochemical assay.
tuspetinib Small molecule or natural product Hs Inhibition 9.0 pIC50 5
⤷ pIC50 9.0 (IC50 1.1x10-9 M) [5]
dovitinib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.5 – 9.0 pIC50 57,63
⤷ pIC50 8.5 – 9.0 (IC50 3x10-9 – 1x10-9 M) [57,63]
compound 34f [PMID: 37535845] Small molecule or natural product Hs Inhibition 8.4 – 9.0 pIC50 4
⤷ pIC50 9.0 (IC50 1x10-9 M) [4]
Description: Inhibition of FLT3-D835Y catalytic activity
pIC50 8.4 (IC50 4x10-9 M) [4]
Description: Inhibition of FLT3-ITD catalytic activity
compound 2c [PMID: 24900538] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.7 pIC50 66
⤷ pIC50 8.7 (IC50 2.1x10-9 M) [66]
ENMD-2076 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.5 pIC50 56
⤷ pIC50 8.5 (IC50 3x10-9 M) [56]
linifanib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.4 pIC50 2
⤷ pIC50 8.4 (IC50 4x10-9 M) [2]
URMC-099 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.4 pIC50 23
⤷ pIC50 8.4 (IC50 4x10-9 M) [23]
compound 18e [PMID: 31670517] Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition 8.4 pIC50 78
⤷ pIC50 8.4 (IC50 4x10-9 M) [78]
quizartinib Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.4 pIC50 81
⤷ pIC50 8.4 (IC50 4.2x10-9 M) [81]
mivavotinib Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition 8.3 pIC50 35
⤷ pIC50 8.3 (IC50 4.6x10-9 M) [35]
Description: In vitro potency
AKN-028 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.2 pIC50 16
⤷ pIC50 8.2 (IC50 6x10-9 M) [16]
sunitinib Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.2 pIC50 31
⤷ pIC50 8.2 (IC50 6.5x10-9 M) [31]
KW-2449 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 8.2 pIC50 60
⤷ pIC50 8.2 (IC50 6.6x10-9 M) [60]
sitravatinib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.1 pIC50 54
⤷ pIC50 8.1 (IC50 8x10-9 M) [54]
Description: In a biochemical enzyme activity assay.
compound 25ap [PMID: 37796543] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.0 pIC50 82
⤷ pIC50 8.0 (IC50 1.09x10-8 M) [82]
compound 7d [PMID: 29672049] Small molecule or natural product Immunopharmacology Ligand Hs Inhibition 7.9 pIC50 26
⤷ pIC50 7.9 (IC50 1.3x10-8 M) [26]
Description: In a biochemical assay.
MELK-TI Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.7 pIC50 29
⤷ pIC50 7.7 (IC50 1.8x10-8 M) [29]
Description: Measured in a MIllipore kinase screening panel assay
tafetinib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.7 pIC50 65
⤷ pIC50 7.7 (IC50 2.08x10-8 M) [65]
Description: In a radiometric biochemical protein kinase assay.
pacritinib Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.7 pIC50 71
⤷ pIC50 7.7 (IC50 2.2x10-8 M) [71]
MK-2461 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.7 pIC50 51
⤷ pIC50 7.7 (IC50 2.2x10-8 M) [51]
JNJ-28312141 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.5 pIC50 46
⤷ pIC50 7.5 (IC50 3x10-8 M) [46]
merestinib Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition 7.5 pIC50 76
⤷ pIC50 7.5 (IC50 3.1x10-8 M) [76]
Description: Inhibition of in vitro biochemical activity by EMD Millipore assay.
zotiraciclib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.3 – 7.7 pIC50 22,72
⤷ pIC50 7.3 – 7.7 (IC50 5.6x10-8 – 1.9x10-8 M) [22,72]
Flt-3 inhibitor II Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 7.5 pIC50 45
⤷ pIC50 7.5 (IC50 3.3x10-8 M) [45]
Flt-3 inhibitor Small molecule or natural product Primary target of this compound Hs Inhibition 7.4 pIC50 52
⤷ pIC50 7.4 (IC50 4.2x10-8 M) [52]
SGI-1776 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.4 pIC50 15
⤷ pIC50 7.4 (IC50 4.4x10-8 M) [15]
sorafenib Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.2 – 7.5 pIC50 70,80
⤷ pIC50 7.5 (IC50 3.3x10-8 M) [80]
pIC50 7.2 (IC50 5.8x10-8 M) [70]
Flt-3 inhibitor III Small molecule or natural product Primary target of this compound Hs Inhibition 7.3 pIC50 18
⤷ pIC50 7.3 (IC50 5x10-8 M) [18]
ruserontinib Small molecule or natural product Hs Inhibition 7.3 pIC50 8
⤷ pIC50 7.3 (IC50 5.5x10-8 M) [8]
ceritinib Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.2 pIC50 48
⤷ pIC50 7.2 (IC50 6x10-8 M) [48]
compound 13ac [PMID: 33256400] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.2 pIC50 77
⤷ pIC50 7.2 (IC50 6.2x10-8 M) [77]
UNC8969 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.2 pIC50 34
⤷ pIC50 7.2 (IC50 7x10-8 M) [34]
PF-562271 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.0 pIC50 58
⤷ pIC50 7.0 (IC50 9.7x10-8 M) [58]
compound 14k [PMID: 21982499] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.0 pIC50 55
⤷ pIC50 7.0 (IC50 1.04x10-7 M) [55]
BMS-690514 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.0 pIC50 47
⤷ pIC50 7.0 (IC50 1.1x10-7 M) [47]
BAY-985 Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 6.9 pIC50 38
⤷ pIC50 6.9 (IC50 1.23x10-7 M) [38]
pexidartinib Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.8 pIC50 61
⤷ pIC50 6.8 (IC50 1.6x10-7 M) [61]
edicotinib Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 6.7 pIC50 20
⤷ pIC50 6.7 (IC50 1.9x10-7 M) [20]
tandutinib Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 6.7 pIC50 30
⤷ pIC50 6.7 (IC50 2.2x10-7 M) [30]
nuvisertib Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.6 pIC50 17
⤷ pIC50 6.6 (IC50 2.79x10-7 M) [17]
GTP-14564 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 6.5 pIC50 50
⤷ pIC50 6.5 (IC50 3x10-7 M) [50]
onvansertib Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.3 pIC50 6
⤷ pIC50 6.3 (IC50 5.1x10-7 M) [6]
AST-487 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 6.3 pIC50 1
⤷ pIC50 6.3 (IC50 5.2x10-7 M) [1]
midostaurin Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibition 6.3 pIC50 68
⤷ pIC50 6.3 (IC50 5.28x10-7 M) [68]
cediranib Small molecule or natural product Click here for species-specific activity table Hs Inhibition <6.0 pIC50 67
⤷ pIC50 <6.0 (IC50 >1x10-6 M) [67]
compound 1 [Cruz-López et al., 2019] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 4.3 pIC50 12
⤷ pIC50 4.3 (IC50 5.35x10-5 M) [12]
Inhibitor Comments
Cyclin-dependent kinase 1 (CDK1) which shares a phenylalanine gate keeper residue in the analogous position to that in FLT3, is significantly inhibited by Flt-3 inhibitor III but with a much lower IC50 value of 2100μM [18]. c-Kit and KDR (VEGFR-2) which contain a cysteine residue at the position corresponding to Cys828 important in the binding pocket of FLT3, are also inhibited by this compound, with IC50 values of 260 and 910μM respectively [18].
G-749 inhibits FLT3 mutant D835Y with an IC50 value of 0.6nM [36].
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
LWY713 Small molecule or natural product Hs Binding - - 41
⤷ PROTAC [41]
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 13,73
Key to terms and symbols Click column headers to sort
Target used in screen: FLT3
Ligand Sp. Type Action Value Parameter
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 9.4 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 9.3 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 9.2 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 9.2 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 9.1 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 9.1 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 9.1 pKd
quizartinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 8.9 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.5 pKd
tandutinib Small molecule or natural product Hs Inhibitor Inhibition 8.5 pKd
Target used in screen: FLT3(D835H)
Ligand Sp. Type Action Value Parameter
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 9.2 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 9.2 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.9 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.7 pKd
JNJ-28312141 Small molecule or natural product Hs Inhibitor Inhibition 8.6 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 8.6 pKd
quizartinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 8.4 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 8.4 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 8.3 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.3 pKd
Target used in screen: FLT3(D835Y)
Ligand Sp. Type Action Value Parameter
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 9.4 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 9.2 pKd
JNJ-28312141 Small molecule or natural product Hs Inhibitor Inhibition 8.8 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.7 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.7 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 8.6 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.6 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 8.3 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 8.2 pKd
fedratinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 8.2 pKd
Target used in screen: FLT3(ITD)
Ligand Sp. Type Action Value Parameter
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 9.3 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 9.0 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 8.8 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 8.7 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.6 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.6 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 8.4 pKd
JNJ-28312141 Small molecule or natural product Hs Inhibitor Inhibition 8.4 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.1 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 8.1 pKd
Target used in screen: FLT3(K663Q)
Ligand Sp. Type Action Value Parameter
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 9.7 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 9.3 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 9.2 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 9.1 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 9.1 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 9.0 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 8.9 pKd
tandutinib Small molecule or natural product Hs Inhibitor Inhibition 8.8 pKd
midostaurin Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 8.7 pKd
quizartinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 8.7 pKd
Target used in screen: FLT3(N841I)
Ligand Sp. Type Action Value Parameter
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 8.9 pKd
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.8 pKd
tamatinib Small molecule or natural product