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Molecular properties generated using the CDK
|Compound class||Synthetic organic|
|RGB 286638 | RGB286638|
|RGB-286638 is a multi-targeted kinase inhibitor. It inhibits transcriptional-type CDKs (cyclin dependent kinases) such as CDK9, to achieve an anti-multiple myeloma effect which is independent of p53 status , providing a proof of concept which could lead to the development of compounds with activity in p53 deleted multiple myeloma.
A Phase I safety and tolerability study, NCT01168882, was withdrawn from ClinicalTrials.gov (2012), although results of this study have been published..
|CAS Registry No.||784210-88-4|
|GtoPdb PubChem SID||223366077|
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