RG-1530

Ligand id: 10361

Name: RG-1530

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 66.59
Molecular weight 356.08
XLogP 5.83
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
5-(2-chlorophenyl)-7-fluoro-8-methoxy-3-methyl-2,10-dihydropyrazolo[3,4-b][1,4]benzodiazepine
Synonyms
compound 2 [PMID: 24900658] | R-1530 | R1530 | RG1530
Comments
RG-1530 is an orally active multikinase inhibitor, with a high affinity for polo like kinase 4 (PLK4). Its PLK4 inhibitory action was expoited for antiproliferative potential [1-4]. PLK4 is expressed at very low levels in normal cells, but its expression can be upregulated in cancer cells where it localises to the centriole and is essential for controlling centriole duplication and mitotic progression. This makes PLK4 an ideal target for disrupting mitosis in cancer cells.
Database Links
BindingDB Ligand 50426474
ChEMBL Ligand CHEMBL1980391
GtoPdb PubChem SID 384403641
PubChem CID 135398512
Search Google for chemical match using the InChIKey UOVCGJXDGOGOCZ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone UOVCGJXDGOGOCZ
Search UniChem for chemical match using the InChIKey UOVCGJXDGOGOCZ-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone UOVCGJXDGOGOCZ