mivavotinib

Ligand id: 9600

Name: mivavotinib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 97.86
Molecular weight 344.18
XLogP 1.44
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
6-[[(1R,2S)-2-aminocyclohexyl]amino]-7-fluoro-4-(1-methylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one
International Nonproprietary Names
INN number INN
10836 mivavotinib
Synonyms
compound 3b [PMID: 27839918] | TAK-659 | TAK659
Comments
Mivavotinib (TAK-659) an orally available inhibitor of spleen tyrosine kinase (SYK), which is in clinical development for solid tumour and lymphoma malignancies. We have drawn the structure as represented in [1].
Database Links
GtoPdb PubChem SID 340590230
PubChem CID 53252276
RCSB PDB Ligand 7KG
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