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target has curated data in GtoImmuPdb
Target id: 2886
Nomenclature: kynurenine 3-monooxygenase
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 2 | 486 | 1q43 | KMO | kynurenine 3-monooxygenase | 1 |
Mouse | 2 | 479 | 1 H3 | Kmo | kynurenine 3-monooxygenase | |
Rat | 2 | 478 | 13q25 | Kmo | kynurenine 3-monooxygenase |
Previous and Unofficial Names ![]() |
kynurenine 3-hydroxylase | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
Database Links ![]() |
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Alphafold | O15229 (Hs), Q91WN4 (Mm), O88867 (Rn) |
BRENDA | 1.14.13.9 |
CATH/Gene3D | 3.50.50.60 |
ChEMBL Target | CHEMBL2145 (Hs), CHEMBL3407318 (Mm), CHEMBL3457 (Rn) |
Ensembl Gene | ENSG00000117009 (Hs), ENSMUSG00000039783 (Mm), ENSRNOG00000003709 (Rn), ENSG00000117009, ENSRNOG00000003709 |
Entrez Gene | 8564 (Hs), 98256 (Mm), 59113 (Rn) |
Human Protein Atlas | ENSG00000117009 (Hs) |
KEGG Enzyme | 1.14.13.9 |
KEGG Gene | hsa:8564 (Hs), mmu:98256 (Mm), rno:59113 (Rn) |
OMIM | 603538 (Hs) |
Pharos | O15229 (Hs) |
RefSeq Nucleotide | NM_003679 (Hs), NM_133809 (Mm), NM_021593 (Rn) |
RefSeq Protein | NP_003670 (Hs), NP_598570 (Mm), NP_067604 (Rn) |
UniProtKB | O15229 (Hs), Q91WN4 (Mm), O88867 (Rn) |
Wikipedia | KMO (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
GSK180-induced inhibition of KMO prevents multiple organ failure in rodent models of acute pancreatitis which is caused by excessive alcohol consumption [3], and which is an inflammatory condition in humans for which there is no current therapy. A Phase 1 trial of GSK's clinical stage KMO inhibitor GSK065/GSK3335065 in healthy subjects was terminated (see NCT03245619). |
Immuno Process Associations | ||
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1. Alberati-Giani D, Cesura AM, Broger C, Warren WD, Röver S, Malherbe P. (1997) Cloning and functional expression of human kynurenine 3-monooxygenase. FEBS Lett, 410 (2-3): 407-12. [PMID:9237672]
2. Hutchinson JP, Rowland P, Taylor MRD, Christodoulou EM, Haslam C, Hobbs CI, Holmes DS, Homes P, Liddle J, Mole DJ et al.. (2017) Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun, 8: 15827. [PMID:28604669]
3. Mole DJ, Webster SP, Uings I, Zheng X, Binnie M, Wilson K, Hutchinson JP, Mirguet O, Walker A, Beaufils B et al.. (2016) Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis. Nat Med, 22 (2): 202-9. [PMID:26752518]
1.14.13.9 Kynurenine 3-monooxygenase: kynurenine 3-monooxygenase. Last modified on 08/04/2019. Accessed on 25/03/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2886.