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tripartite motif containing 38

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2984

Nomenclature: tripartite motif containing 38

Systematic Nomenclature: TRIM38

Family: RING-type E3 ubiquitin transferase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 465 6p22.2 TRIM38 tripartite motif containing 38
Mouse - 471 13 A3.1 Trim38 tripartite motif-containing 38
Rat - - 17p11 Trim38 tripartite motif containing 38
Previous and Unofficial Names Click here for help
ring finger protein 15 | RNF15 | RORET | tripartite motif-containing 38
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:
Description Reaction Reference
Transfer of ubiquitin to L-lysine residue of the acceptor protein. S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine <=> [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Immunopharmacology Comments
TRIM38 catalyses the ubiquitination of Lys48 of the Toll-like receptor (TLR) adaptor protein TICAM1 (commonly referred to as TRIF) which mediates its proteosomal degradation. This action has been shown to inhibit TLR3-driven type I interferon signaling of the innate immune response [2]. The participation of TRIM38 in immune and inflammatory response regulation is reviewed by Hu and Shu (2017) [1].
Immuno Process Associations
Immuno Process:  Barrier integrity
Immuno Process:  Inflammation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling
Immuno Process:  Immune regulation
General Comments
TRIM38 is an E3 ubiquitin ligase. It is required for innate immune response initiation upon detection of viral RNA or DNA by dedicated sensors [1].


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1. Hu MM, Shu HB. (2017) Multifaceted roles of TRIM38 in innate immune and inflammatory responses. Cell Mol Immunol, 14 (4): 331-338. [PMID:28194022]

2. Xue Q, Zhou Z, Lei X, Liu X, He B, Wang J, Hung T. (2012) TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation. PLoS ONE, 7 (10): e46825. [PMID:23056470]

How to cite this page RING-type E3 ubiquitin transferase: tripartite motif containing 38. Last modified on 05/02/2018. Accessed on 25/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,