Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	465	6p22.2	TRIM38	tripartite motif containing 38
Mouse	-	471	13 A3.1	Trim38	tripartite motif-containing 38
Rat	-	-	17p11	Trim38	tripartite motif containing 38

Previous and Unofficial Names

ring finger protein 15 | RNF15 | RORET | tripartite motif-containing 38

Database Links
Alphafold	O00635 (Hs)
BRENDA	2.3.2.27
Ensembl Gene	ENSG00000112343 (Hs), ENSMUSG00000064140 (Mm)
Entrez Gene	10475 (Hs), 214158 (Mm), 680019 (Rn)
Human Protein Atlas	ENSG00000112343 (Hs)
KEGG Enzyme	2.3.2.27
KEGG Gene	hsa:10475 (Hs), mmu:214158 (Mm), rno:680019 (Rn)
Pharos	O00635 (Hs)
RefSeq Nucleotide	NM_006355 (Hs), NM_001029935 (Mm)
RefSeq Protein	NP_006346 (Hs), NP_001025106 (Mm)
UniProtKB	O00635 (Hs)
Wikipedia	TRIM38 (Hs)

Enzyme Reaction
EC Number: 2.3.2.27 Description Reaction Reference Transfer of ubiquitin to L-lysine residue of the acceptor protein. S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine <=> [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine

Immunopharmacology Comments

TRIM38 catalyses the ubiquitination of Lys48 of the Toll-like receptor (TLR) adaptor protein TICAM1 (commonly referred to as TRIF) which mediates its proteosomal degradation. This action has been shown to inhibit TLR3-driven type I interferon signaling of the innate immune response [2]. The participation of TRIM38 in immune and inflammatory response regulation is reviewed by Hu and Shu (2017) [1].

Immuno Process Associations

Immuno Process:  Barrier integrity

Immuno Process:  Inflammation

Immuno Process:  Cytokine production & signalling

Immuno Process:  Cellular signalling

Immuno Process:  Immune regulation

General Comments
TRIM38 is an E3 ubiquitin ligase. It is required for innate immune response initiation upon detection of viral RNA or DNA by dedicated sensors [1].