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| Quaternary Structure: Complexes |
| Thymic stromal lymphopoietin receptor |
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 371 | Xp22.3 and Yp11.3 | CRLF2 | cytokine receptor like factor 2 | |
| Mouse | 1 | 359 | 5 F | Crlf2 | cytokine receptor-like factor 2 | |
| Rat | 1 | 360 | 14p22 | Crlf2 | cytokine receptor-like factor 2 | |
| Previous and Unofficial Names |
| thymic stromal lymphopoietin protein receptor | Tpte2 | TSLP receptor | Ly114 | CRL2 | transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 |
| Database Links |
|
| Alphafold | Q9HC73 (Hs), Q8CII9 (Mm), Q8R4S8 (Rn) |
| CATH/Gene3D | 2.60.40.10 |
| Ensembl Gene | ENSG00000205755 (Hs), ENSMUSG00000033467 (Mm), ENSRNOG00000049828 (Rn) |
| Entrez Gene | 64109 (Hs), 57914 (Mm), 171499 (Rn) |
| Human Protein Atlas | ENSG00000205755 (Hs) |
| KEGG Gene | hsa:64109 (Hs), mmu:57914 (Mm), rno:171499 (Rn) |
| OMIM | 300357 (Hs) |
| Pharos | Q9HC73 (Hs) |
| UniProtKB | Q9HC73 (Hs), Q8CII9 (Mm), Q8R4S8 (Rn) |
| Wikipedia | CRLF2 (Hs) |
| Immunopharmacology Comments |
| Cytokine receptor-like factor 2 is the signal transducing subunit of the functional heterodimeric receptor for thymic stromal lymphopoietin (TSLP). Ligand binding is attributed to the interleukin-7 receptor subunit α. |
IL-2 receptor family: Cytokine receptor-like factor 2. Last modified on 10/04/2017. Accessed on 24/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1704.
target has curated data in GtoImmuPdb
