Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	380	Xq23	IL13RA2	interleukin 13 receptor subunit alpha 2
Mouse	1	383	X 68.46 cM	Il13ra2	interleukin 13 receptor, alpha 2
Rat	1	385	Xq34	Il13ra2	interleukin 13 receptor subunit alpha 2

Previous and Unofficial Names

interleukin 13 receptor | cancer/testis antigen 19 | CD213a2 | CT19 | IL13BP | IL-13RA2 | IL-13 receptor alpha-2 | IL-13R subunit alpha-2

Database Links
Alphafold	Q14627 (Hs), O88786 (Mm), Q8VHK6 (Rn)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL3713941 (Hs)
Ensembl Gene	ENSG00000123496 (Hs), ENSMUSG00000031289 (Mm), ENSRNOG00000032973 (Rn)
Entrez Gene	3598 (Hs), 16165 (Mm), 171060 (Rn)
Human Protein Atlas	ENSG00000123496 (Hs)
KEGG Gene	hsa:3598 (Hs), mmu:16165 (Mm), rno:171060 (Rn)
OMIM	300130 (Hs)
Pharos	Q14627 (Hs)
UniProtKB	Q14627 (Hs), O88786 (Mm), Q8VHK6 (Rn)
Wikipedia	IL13RA2 (Hs)

Immunopharmacology Comments

Interleukin 13 receptor, α2 acts as a high affinity decoy receptor for interleukin 13 that sequesters the ligand away from IL13Rα1 and is involved in down-regulating IL-13 responses in vivo. IL13ra2 null mice exhibit enhanced IL-13 responses [4]. Increased expression of IL13Rα2 has been reported to promote tumor progression in glioma and other tumor models, and its expression is a prognostic marker for glioma malignancy grade and for poor patient survival [1,3]. This receptor has not been detected on normal brian tissue, making IL13Rα2 a novel selective drug target that has been intensively investigated for the treatment of glioblastoma, with several immunotherapeutic candidates advancing to clinical trial (reviewed in [2]).

Immuno Process Associations

Immuno Process:  B cell (activation) GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0016064 immunoglobulin mediated immune response IEA

Immuno Process:  Cellular signalling GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0043305 negative regulation of mast cell degranulation IEA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 3 GO processes GO:0004896 cytokine receptor activity IDA GO:0019221 cytokine-mediated signaling pathway IBA GO:0035772 interleukin-13-mediated signaling pathway IDA

Immuno Process:  Immune regulation GO Annotations:  Associated to 2 GO processes, IEA only click arrow to show/hide IEA associations GO:0002638 negative regulation of immunoglobulin production IEA GO:0043305 negative regulation of mast cell degranulation IEA

Immuno Process:  Inflammation GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0043305 negative regulation of mast cell degranulation IEA

Immuno Process:  T cell (activation) GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0016064 immunoglobulin mediated immune response IEA