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Target not currently curated in GtoImmuPdb
Target id: 2976
Nomenclature: protein tyrosine phosphatase non-receptor type 1
Abbreviated Name: PTP1B
Family: Protein tyrosine phosphatases non-receptor type (PTPN)
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 435 | 20q13.13 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 | 1 |
Mouse | - | 432 | 2 H3 | Ptpn1 | protein tyrosine phosphatase, non-receptor type 1 | |
Rat | - | 432 | 3q42 | Ptpn1 | protein tyrosine phosphatase, non-receptor type 1 | |
Gene and Protein Information Comments | ||||||
A second isoform from the human gene with a shorter N-terminus has been detected (RefSeq NP_001265547). |
Previous and Unofficial Names ![]() |
protein tyrosine phosphatase | protein tyrosine phosphatase, non-receptor type 1 | PTP1B |
Database Links ![]() |
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Alphafold | P18031 (Hs), P35821 (Mm), P20417 (Rn) |
BRENDA | 3.1.3.48 |
ChEMBL Target | CHEMBL335 (Hs), CHEMBL3336 (Mm), CHEMBL2371 (Rn) |
Ensembl Gene | ENSG00000196396 (Hs), ENSMUSG00000027540 (Mm), ENSRNOG00000010574 (Rn) |
Entrez Gene | 5770 (Hs), 19246 (Mm), 24697 (Rn) |
Human Protein Atlas | ENSG00000196396 (Hs) |
KEGG Enzyme | 3.1.3.48 |
KEGG Gene | hsa:5770 (Hs), mmu:19246 (Mm), rno:24697 (Rn) |
OMIM | 176885 (Hs) |
Pharos | P18031 (Hs) |
RefSeq Nucleotide | NM_002827 (Hs), NM_011201 (Mm), NM_012637 (Rn) |
RefSeq Protein | NP_002818 (Hs), NP_035331 (Mm), NP_036769 (Rn) |
UniProtKB | P18031 (Hs), P35821 (Mm), P20417 (Rn) |
Wikipedia | PTPN1 (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
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Immuno Process Associations | |||||||||
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General Comments |
PTPN1 (a.k.a. PTP1B) is a non-receptor protein tyrosine phosphatase. It negatively regulates insulin signalling by dephosphorylating the phosphotryosine residues on the insulin receptor. It is a potential drug target for the treatment of type 2 diabetes (insulin resistance) [5]. PTPN1 inhibitors have been reported to have hypoglycaemic and other anti-diabetic effects [6,8]. |
1. Brown-Shimer S, Johnson KA, Lawrence JB, Johnson C, Bruskin A, Green NR, Hill DE. (1990) Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B. Proc Natl Acad Sci USA, 87 (13): 5148-52. [PMID:2164224]
2. Haftchenary S, Ball DP, Aubry I, Landry M, Shahani VM, Fletcher S, Page BDG, Jouk AO, Tremblay ML, Gunning PT. (2013) Identification of a potent salicylic acid-based inhibitor of tyrosine phosphatase PTP1B. Medchemcomm, (4): 987-992.
3. Lantz KA, Hart SG, Planey SL, Roitman MF, Ruiz-White IA, Wolfe HR, McLane MP. (2010) Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring), 18 (8): 1516-23. [PMID:20075852]
4. Li K, Hou X, Li R, Bi W, Yang F, Chen X, Xiao P, Liu T, Lu T, Zhou Y et al.. (2019) Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22. J Biol Chem, 294 (21): 8653-8663. [PMID:30979725]
5. Liu G, Trevillyan JM. (2002) Protein tyrosine phosphatase 1B as a target for the treatment of impaired glucose tolerance and type II diabetes. Curr Opin Investig Drugs, 3 (11): 1608-16. [PMID:12476961]
6. Luo J, Xu Q, Jiang B, Zhang R, Jia X, Li X, Wang L, Guo C, Wu N, Shi D. (2018) Selectivity, cell permeability and oral availability studies of novel bromophenol derivative HPN as protein tyrosine phosphatase 1B inhibitor. Br J Pharmacol, 175 (1): 140-153. [PMID:29059712]
7. Shi D, Guo S, Jiang B, Guo C, Wang T, Zhang L, Li J. (2013) HPN, a synthetic analogue of bromophenol from red alga Rhodomela confervoides: synthesis and anti-diabetic effects in C57BL/KsJ-db/db mice. Mar Drugs, 11 (2): 350-62. [PMID:23364683]
8. Taylor SD, Hill B. (2004) Recent advances in protein tyrosine phosphatase 1B inhibitors. Expert Opin Investig Drugs, 13 (3): 199-214. [PMID:15013940]
9. Yu X, Sun JP, He Y, Guo X, Liu S, Zhou B, Hudmon A, Zhang ZY. (2007) Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc Natl Acad Sci USA, 104 (50): 19767-72. [PMID:18056643]
Protein tyrosine phosphatases non-receptor type (PTPN): protein tyrosine phosphatase non-receptor type 1. Last modified on 06/05/2019. Accessed on 17/08/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2976.