Protein tyrosine phosphatases non-receptor type (PTPN)

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Protein tyrosine phosphatases non-receptor type (PTPN)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Protein tyrosine phosphatases (PTPs) catalyse the hydrolysis of phosphate monoesters on tyrosine residues, in opposition to tyrosine kinase-catalysed phosphorylation.
The HGNC lists 17 members in the 'Protein tyrosine phosphatases, non-receptor type (PTPN)' family (ID 812).

Enzymes

PTP1B (protein tyrosine phosphatase non-receptor type 1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2976

Nomenclature

protein tyrosine phosphatase non-receptor type 1

Common abbreviation

PTP1B

Previous and unofficial names

protein tyrosine phosphatase | protein tyrosine phosphatase, non-receptor type 1 | PTP1B

Genes

PTPN1 (Hs), Ptpn1 (Mm), Ptpn1 (Rn)

Ensembl ID

ENSG00000196396 (Hs), ENSMUSG00000027540 (Mm), ENSRNOG00000010574 (Rn)

UniProtKB AC

P18031 (Hs), P35821 (Mm), P20417 (Rn)

EC number

3.1.3.48
Dephosphorylates O-phosphotyrosine groups in phosphoproteins. Protein tyrosine phosphate + H₂O <=> protein tyrosine + phosphate

SHP2 (protein tyrosine phosphatase non-receptor type 11) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

3203

Nomenclature

protein tyrosine phosphatase non-receptor type 11

Common abbreviation

SHP2

Previous and unofficial names

Noonan syndrome 1 (NS1) | SH2 domain-containing protein tyrosine phosphatase 2 | SHP-2 | src homology region 2 domain phosphatase | Src homology-2 domain-containing phosphatase Shp2

Genes

PTPN11 (Hs)

Ensembl ID

ENSG00000179295 (Hs)

UniProtKB AC

Q06124 (Hs)

EC number

3.1.3.48

Comment

PTPN11 (also known as SHP2) is a cytosolic protein-tyrosine phosphatase. It is an important convergent node that activates multiple RAS signalling pathways in human diseases, and it is an active molecular target for cancer therapy development [2-3].

LYP (protein tyrosine phosphatase non-receptor type 22 / PTPN22) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

3084

Nomenclature

protein tyrosine phosphatase non-receptor type 22

Systematic nomenclature

PTPN22

Common abbreviation

LYP

Previous and unofficial names

Genes

PTPN22 (Hs), Ptpn22 (Mm), Ptpn22 (Rn)

Ensembl ID

ENSG00000134242 (Hs), ENSMUSG00000027843 (Mm), ENSRNOG00000019614 (Rn)

UniProtKB AC

Q9Y2R2 (Hs), P29352 (Mm)

EC number

3.1.3.48
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate [4]

References

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1. Cohen S, Dadi H, Shaoul E, Sharfe N, Roifman CM. (1999) Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp. Blood, 93 (6): 2013-24. [PMID:10068674]

2. Nagasaka M, Azmi AS. (2022) Clinical progress of KRAS-targeted therapies: what next?. Future Med Chem, [Epub ahead of print]. DOI: 10.4155/fmc-2022-0128 [PMID:35758004]

3. Song Z, Wang M, Ge Y, Chen XP, Xu Z, Sun Y, Xiong XF. (2021) Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies. Acta Pharm Sin B, 11 (1): 13-29. [PMID:33532178]

4. Yu X, Chen M, Zhang S, Yu ZH, Sun JP, Wang L, Liu S, Imasaki T, Takagi Y, Zhang ZY. (2011) Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate. J Biol Chem, 286 (35): 30526-34. [PMID:21719704]

How to cite this family page

Database page citation:

Protein tyrosine phosphatases non-receptor type (PTPN). Accessed on 26/03/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=980.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.