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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 479 | 2q33.1 | CASP8 | caspase 8 | |
| Mouse | - | 480 | 1 29.19 cM | Casp8 | caspase 8 | |
| Rat | - | 482 | 9q31 | Casp8 | caspase 8 | |
| Previous and Unofficial Names |
| apoptotic protease Mch-5 | CAP4 | CE-like apoptotic protease 5 | FADD-homologous ICE/CED-3-like protease | FADD-like ICE | FLICE | MACH | MCH5 | caspase 8, apoptosis-related cysteine peptidase |
| Database Links |
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| Specialist databases | |
| MEROPS | C14.009 (Hs) |
| Other databases | |
| Alphafold | Q14790 (Hs), O89110 (Mm), Q9JHX4 (Rn) |
| BRENDA | 3.4.22.61 |
| ChEMBL Target | CHEMBL3776 (Hs), CHEMBL4630806 (Mm) |
| Ensembl Gene | ENSG00000064012 (Hs), ENSMUSG00000026029 (Mm), ENSRNOG00000012331 (Rn) |
| Entrez Gene | 841 (Hs), 12370 (Mm), 64044 (Rn) |
| Human Protein Atlas | ENSG00000064012 (Hs) |
| KEGG Enzyme | 3.4.22.61 |
| KEGG Gene | hsa:841 (Hs), mmu:12370 (Mm), rno:64044 (Rn) |
| OMIM | 601763 (Hs) |
| Orphanet | ORPHA138851 (Hs) |
| Pharos | Q14790 (Hs) |
| RefSeq Nucleotide | NM_033355 (Hs), NM_001080124 (Hs), NM_001228 (Hs), NM_001080125 (Hs), NM_033358 (Hs), NM_033356 (Hs), NM_001080126 (Mm), NM_009812 (Mm), NM_022277 (Rn) |
| RefSeq Protein | NP_001219 (Hs), NP_203519 (Hs), NP_203520 (Hs), NP_001073593 (Hs), NP_203522 (Hs), NP_001073594 (Hs), NP_001073595 (Mm), NP_033942 (Mm), NP_071613 (Rn) |
| UniProtKB | Q14790 (Hs), O89110 (Mm), Q9JHX4 (Rn) |
| Wikipedia | CASP8 (Hs) |
| Enzyme Reaction |
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| Substrates and Reaction Kinetics |
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| Endogenous activators (Human) |
| DISC |
Download all structure-activity data for this target as a CSV file 
| Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Immunopharmacology Comments |
| Roles of apoptotic caspases extending beyond cell death, for example, mediating cellular immune processes such as inflammasome modulation, necroptosis and pro-inflammatory cytokine processing have been reported [7]. Specifically caspase 8 can counteract necroptosis, an inflammatory mode of cell death induced by receptor-interacting protein (RIP)3, and may be involved in IL-1β maturation during fungal and mycobacterial infections [8]. |
| Immuno Process Associations | ||
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| Clinically-Relevant Mutations and Pathophysiology
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1. Choong IC, Lew W, Lee D, Pham P, Burdett MT, Lam JW, Wiesmann C, Luong TN, Fahr B, DeLano WL et al.. (2002) Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem, 45 (23): 5005-22. [PMID:12408711]
2. Cox A, Dunning AM, Garcia-Closas M, Balasubramanian S, Reed MW, Pooley KA, Scollen S, Baynes C, Ponder BA, Chanock S et al.. (2007) A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet, 39 (3): 352-8. [PMID:17293864]
3. Frank B, Bermejo JL, Hemminki K, Klaes R, Bugert P, Wappenschmidt B, Schmutzler RK, Burwinkel B. (2005) Re: Association of a common variant of the CASP8 gene with reduced risk of breast cancer. J Natl Cancer Inst, 97 (13): 1012; author reply 1012-3. [PMID:15998955]
4. Gregoli PA, Bondurant MC. (1999) Function of caspases in regulating apoptosis caused by erythropoietin deprivation in erythroid progenitors. J Cell Physiol, 178 (2): 133-43. [PMID:10048577]
5. Linton SD, Aja T, Armstrong RA, Bai X, Chen LS, Chen N, Ching B, Contreras P, Diaz JL, Fisher CD et al.. (2005) First-in-class pan caspase inhibitor developed for the treatment of liver disease. J Med Chem, 48 (22): 6779-82. [PMID:16250635]
6. MacPherson G, Healey CS, Teare MD, Balasubramanian SP, Reed MW, Pharoah PD, Ponder BA, Meuth M, Bhattacharyya NP, Cox A. (2004) Association of a common variant of the CASP8 gene with reduced risk of breast cancer. J Natl Cancer Inst, 96 (24): 1866-9. [PMID:15601643]
7. Man SM, Kanneganti TD. (2016) Converging roles of caspases in inflammasome activation, cell death and innate immunity. Nat Rev Immunol, 16 (1): 7-21. [PMID:26655628]
8. Rodrigue-Gervais IG, Saleh M. (2013) Caspases and immunity in a deadly grip. Trends Immunol, 34 (2): 41-9. [PMID:23069594]
9. Sun T, Gao Y, Tan W, Ma S, Shi Y, Yao J, Guo Y, Yang M, Zhang X, Zhang Q et al.. (2007) A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers. Nat Genet, 39 (5): 605-13. [PMID:17450141]
C14: Caspase: Caspase 8. Last modified on 10/02/2017. Accessed on 25/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1624.
target has curated data in GtoImmuPdb
