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Gene and Protein Information  |
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| class A G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 362 | 17q21.2 | CCR10 | C-C motif chemokine receptor 10 | 2-3,7,9,13 |
| Mouse | 7 | 362 | 11 64.34 cM | Ccr10 | C-C motif chemokine receptor 10 | 7,12-13 |
| Rat | 7 | - | 10q32.1 | Ccr10 | C-C motif chemokine receptor 10 | |
| Previous and Unofficial Names |
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| GPR-2 [4,13] | |
| Database Links |
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| Specialist databases | |
| GPCRdb | ccr10_human (Hs), ccr10_mouse (Mm) |
| Other databases | |
| Alphafold | P46092 (Hs), Q9JL21 (Mm) |
| ChEMBL Target | CHEMBL2321628 (Hs), CHEMBL3879821 (Mm) |
| Ensembl Gene | ENSG00000184451 (Hs), ENSMUSG00000044052 (Mm), ENSRNOG00000020275 (Rn) |
| Entrez Gene | 2826 (Hs), 12777 (Mm), 363682 (Rn) |
| Human Protein Atlas | ENSG00000184451 (Hs) |
| KEGG Gene | hsa:2826 (Hs), mmu:12777 (Mm), rno:363682 (Rn) |
| OMIM | 600240 (Hs) |
| Pharos | P46092 (Hs) |
| RefSeq Nucleotide | NM_016602 (Hs), NM_007721 (Mm), NM_001108836 (Rn) |
| RefSeq Protein | NP_057686 (Hs), NP_031747 (Mm), NP_001102306 (Rn) |
| UniProtKB | P46092 (Hs), Q9JL21 (Mm) |
| Wikipedia | CCR10 (Hs) |
| Natural/Endogenous Ligands |
| CCL27 {Sp: Human} |
| CCL28 {Sp: Human} |
| CCL27 {Sp: Mouse} |
| CCL28 {Sp: Mouse} |
Download all structure-activity data for this target as a CSV file 
| Agonist Comments | ||
| It has been shown that CCL27 (CTACK/ALP/ILC) [5] and CCL28 (MEC) [13] are both ligands for the CCR10 receptor. |
| Antagonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| View species-specific antagonist tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Immunopharmacology Comments |
| CCR10 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation. |
| Immuno Process Associations | ||
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| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
| Gi/Go family | Calcium channel |
| References: | |
| Tissue Distribution
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| Expression Datasets |
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| Functional Assays
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| Physiological Functions
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Abeywardane A, Caviness G, Choi Y, Cogan D, Gao A, Goldberg D, Heim-Riether A, Jeanfavre D, Klein E, Kowalski JA et al.. (2016) N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg Med Chem Lett, 26 (21): 5277-5283. [PMID:27692854]
2. Bonini JA, Martin SK, Dralyuk F, Roe MW, Philipson LH, Steiner DF. (1997) Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. DNA Cell Biol, 16 (10): 1249-56. [PMID:9364936]
3. Gosling J, Dairaghi DJ, Wang Y, Hanley M, Talbot D, Miao Z, Schall TJ. (2000) Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J Immunol, 164: 2851-2856. [PMID:10706668]
4. Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E et al.. (2002) CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med, 8 (2): 157-65. [PMID:11821900]
5. Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, Muller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, Ruzicka T, Lehmann P, Oldham E, Zlotnik A. (2000) Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J Immunol, 164: 3465-3470. [PMID:10725697]
6. Huber TB, Reinhardt HC, Exner M, Burger JA, Kerjaschki D, Saleem MA, Pavenstädt H. (2002) Expression of functional CCR and CXCR chemokine receptors in podocytes. J Immunol, 168 (12): 6244-52. [PMID:12055238]
7. Jarmin DI, Rits M, Bota D, Gerard NP, Graham GJ, Clark-Lewis I, Gerard C. (2000) Cutting edge: Identification of the orphan receptor G protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. J Immunol, 164: 3460-3464. [PMID:10725696]
8. Lüttichau HR, Lewis IC, Gerstoft J, Schwartz TW. (2001) The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus-encoded chemokine MC148, inhibits the CCR10 receptor. Eur J Immunol, 31 (4): 1217-20. [PMID:11298347]
9. Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF. (1994) Cloning of human genes encoding novel G protein-coupled receptors. Genomics, 23 (3): 609-18. [PMID:7851889]
10. Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang ST. (2003) Immune evasion by murine melanoma mediated through CC chemokine receptor-10. J Exp Med, 198 (9): 1337-47. [PMID:14581607]
11. Soler D, Humphreys TL, Spinola SM, Campbell JJ. (2003) CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. Blood, 101 (5): 1677-82. [PMID:12406880]
12. Townson JR, Nibbs RJ. (2002) Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR. Eur J Immunol, 32 (5): 1230-41. [PMID:11981810]
13. Wang W, Soto H, Oldham ER, Buchanan ME, Homey B, Catron D, Jenkins N, Copeland NG, Gilbert DJ, Nguyen N et al.. (2000) Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J Biol Chem, 275 (29): 22313-23. [PMID:10781587]
target has curated data in GtoImmuPdb
