Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	277	20q13.12	CD40	CD40 molecule
Mouse	1	289	2 85.38 cM	Cd40	CD40 antigen
Rat	-	-		Cd40	CD40 molecule

Previous and Unofficial Names

CD40 molecule, TNF receptor superfamily member 5 | TNFRSF5

Database Links
Alphafold	P25942 (Hs), P27512 (Mm)
ChEMBL Target	CHEMBL1250358 (Hs)
Ensembl Gene	ENSG00000101017 (Hs), ENSMUSG00000017652 (Mm), ENSRNOG00000018488 (Rn)
Entrez Gene	958 (Hs), 21939 (Mm), 171369 (Rn)
Human Protein Atlas	ENSG00000101017 (Hs)
KEGG Gene	hsa:958 (Hs), mmu:21939 (Mm), rno:171369 (Rn)
OMIM	109535 (Hs)
Pharos	P25942 (Hs)
UniProtKB	P25942 (Hs), P27512 (Mm)
Wikipedia	CD40 (Hs)

Natural/Endogenous Ligands
CD40 ligand {Sp: Human}

Adaptor proteins (Human)

TRAF1, TRAF2, TRAF3, TRAF5, TRAF6

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference mitazalimab Hs Agonist 11.0 pKd 2 ⤷ pKd 11.0 (Kd 1x10-11 M) [2] CFZ533 Hs Binding 9.2 pKd 1 ⤷ pKd 9.2 (Kd 6.9x10-10 M) [1] Description: Measured using a Biacore assay.
Antibody Comments
Other anti-CD40 mAbs in clinical development include ABBV-323 (ravagalimab; for Crohn's disease) and JNJ-64457107 (vanalimab, ADC-1013; a CD40 agonistic mAb in Phase 1 immuno-oncology trial NCT02829099)

Other Binding Ligands
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference CD40 ligand {Sp: Human} Hs - - - ⤷

Immunopharmacology Comments

CD40 is a stimulatory receptor and a member of the tumor necrosis factor receptor superfamily (TNFRSF). It is expressed on a variety of immune cells, including macrophages, B cells, and dendritic cells (DCs). CD40 plays a key role in the activation of the immune system. Endogenous ligand is CD154 (CD40L) on TH cells. CD40 is an immunotherapy and immuno-oncology clinical target. Anti-CD40 agonistic monoclonal antibodies that induce activation and proliferation of effector and memory T cells, and enhance the immune response against tumour cells, are in clinical development.

Immuno Process Associations

Immuno Process:  B cell (activation) GO Annotations:  Associated to 5 GO processes, IEA only GO:0042100 B cell proliferation NAS GO:0042113 B cell activation IBA click arrow to show/hide IEA associations GO:0019724 B cell mediated immunity IEA GO:0030890 positive regulation of B cell proliferation IEA GO:0048304 positive regulation of isotype switching to IgG isotypes IEA

Immuno Process:  Cellular signalling GO Annotations:  Associated to 5 GO processes, IEA only GO:0002768 immune response-regulating cell surface receptor signaling pathway IBA GO:0042100 B cell proliferation NAS GO:0042113 B cell activation IBA click arrow to show/hide IEA associations GO:0030890 positive regulation of B cell proliferation IEA GO:0048304 positive regulation of isotype switching to IgG isotypes IEA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 6 GO processes GO:1902216 positive regulation of interleukin-4-mediated signaling pathway IGI click arrow to show/hide IEA associations GO:0032735 positive regulation of interleukin-12 production IEA GO:0034341 response to type II interferon IEA GO:0036018 cellular response to erythropoietin IEA GO:0071347 cellular response to interleukin-1 IEA GO:0071356 cellular response to tumor necrosis factor IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 3 GO processes, IEA only GO:0002768 immune response-regulating cell surface receptor signaling pathway IBA click arrow to show/hide IEA associations GO:0030890 positive regulation of B cell proliferation IEA GO:0048304 positive regulation of isotype switching to IgG isotypes IEA

Immuno Process:  Immune system development GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0048304 positive regulation of isotype switching to IgG isotypes IEA

Immuno Process:  Inflammation GO Annotations:  Associated to 3 GO processes GO:0006954 inflammatory response TAS click arrow to show/hide IEA associations GO:0034341 response to type II interferon IEA GO:0048304 positive regulation of isotype switching to IgG isotypes IEA

Immuno Process:  T cell (activation) GO Annotations:  Associated to 2 GO processes, IEA only click arrow to show/hide IEA associations GO:0019724 B cell mediated immunity IEA GO:0048304 positive regulation of isotype switching to IgG isotypes IEA