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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 784 | 4q31.3 | TLR2 | toll like receptor 2 | |
Mouse | 1 | 784 | 3 E3 | Tlr2 | toll-like receptor 2 | |
Rat | - | - | 2q34 | Tlr2 | toll-like receptor 2 |
Previous and Unofficial Names ![]() |
CD282 | TIL4 | toll-like receptor 2 | Ly105 |
Database Links ![]() |
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CATH/Gene3D | 3.40.50.10140, 3.80.10.10 |
ChEMBL Target | CHEMBL4163 (Hs), CHEMBL1075106 (Mm) |
DrugBank Target | O60603 (Hs) |
Ensembl Gene | ENSG00000137462 (Hs), ENSMUSG00000027995 (Mm), ENSRNOG00000009822 (Rn) |
Entrez Gene | 7097 (Hs), 24088 (Mm), 310553 (Rn) |
Human Protein Atlas | ENSG00000137462 (Hs) |
KEGG Gene | hsa:7097 (Hs), mmu:24088 (Mm), rno:310553 (Rn) |
OMIM | 603028 (Hs) |
Pharos | O60603 (Hs) |
UniProtKB | O60603 (Hs), Q9QUN7 (Mm) |
Wikipedia | TLR2 (Hs) |
Download all structure-activity data for this target as a CSV file
Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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View species-specific agonist tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Agonist Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The unlabelled parent molecule of compound 13 in the table above (compound 10 in [4]) has a Ki of 11nM. |
Antibodies | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
TLR1/2 and 2/6 heterodimers detect and initiate an immune response to triacylated and diacylated [6] lipopeptides respectively [2]. The synthetic lipopeptides Pam3CSK4 and Pam2CSK4 activate TLR1/2 and 2/6 heterodimers respectively. |
Immuno Process Associations | ||||||||||||||||||||||||
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Physiological Functions Comments | |
Involved in the pro-inflammatory response to bacterial lipopeptides. |
Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. Dellacasagrande J. (2011) Humanised antibodies to toll-like receptor 2 and uses thereof. Patent number: WO2011003925. Assignee: Opsona Therapeutics Limited. Priority date: 06/07/2009. Publication date: 13/01/2011.
2. Farhat K, Riekenberg S, Heine H, Debarry J, Lang R, Mages J, Buwitt-Beckmann U, Röschmann K, Jung G, Wiesmüller KH et al.. (2008) Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling. J. Leukoc. Biol., 83 (3): 692-701. [PMID:18056480]
3. Garay RP, Viens P, Bauer J, Normier G, Bardou M, Jeannin JF, Chiavaroli C. (2007) Cancer relapse under chemotherapy: why TLR2/4 receptor agonists can help. Eur. J. Pharmacol., 563 (1-3): 1-17. [PMID:17383632]
4. Huynh AS, Chung WJ, Cho HI, Moberg VE, Celis E, Morse DL, Vagner J. (2012) Novel toll-like receptor 2 ligands for targeted pancreatic cancer imaging and immunotherapy. J. Med. Chem., 55 (22): 9751-62. [PMID:23098072]
5. Morin MD, Wang Y, Jones BT, Mifune Y, Su L, Shi H, Moresco EMY, Zhang H, Beutler B, Boger DL. (2018) Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists. J. Am. Chem. Soc., 140 (43): 14440-14454. [PMID:30272974]
6. Nakao Y, Funami K, Kikkawa S, Taniguchi M, Nishiguchi M, Fukumori Y, Seya T, Matsumoto M. (2005) Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells. J. Immunol., 174 (3): 1566-73. [PMID:15661917]