Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	668	11q12.2	CD6	CD6 molecule
Mouse	1	665	19 7.16 cM	Cd6	CD6 antigen
Rat	-	665	1q43	Cd6	Cd6 molecule
Gene and Protein Information Comments
Details of alternate transcripts and protein isoforms identified for human and mouse CD6 are available from their NCBI (Entrez) gene entries.

Previous and Unofficial Names

Tp120

Database Links
Alphafold	P30203 (Hs)
CATH/Gene3D	3.10.250.10
ChEMBL Target	CHEMBL3712853 (Hs)
Ensembl Gene	ENSG00000013725 (Hs), ENSMUSG00000024670 (Mm), ENSRNOG00000020884 (Rn)
Entrez Gene	923 (Hs), 12511 (Mm), 25752 (Rn)
Human Protein Atlas	ENSG00000013725 (Hs)
KEGG Gene	hsa:923 (Hs), mmu:12511 (Mm), rno:25752 (Rn)
Pharos	P30203 (Hs)
RefSeq Nucleotide	NM_006725 (Hs), NM_009852 (Mm), NM_175577 (Rn)
RefSeq Protein	NP_006716 (Hs), NP_033982 (Mm), NP_783167 (Rn)
UniProtKB	P30203 (Hs), Q61003 (Mm)
Wikipedia	CD6 (Hs)

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference itolizumab Hs Binding 7.2 pKi 1 ⤷ pKi 7.2 (Ki 6x10-8 M) [1]

Immunopharmacology Comments

CD6 is a co-stimulatory molecule, predominantly expressed on lymphocytes and associated with autoimmune responses. CD6 interacts with activated leucocyte-cell adhesion molecule (ALCAM/CD166), found on antigen presenting cells. This interaction induces the production of proinflammatory cytokines [2], prostaglandins, leukotrienes and oxygen free radicals. Druggability is indicated by approval of the anti-CD6 monoclonal antibody itolizumab to treat psoriasis.

Cell Type Associations

Immuno Cell Type:  B cells

Immuno Cell Type:  T cells

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 3 GO processes GO:0002438 acute inflammatory response to antigenic stimulus IDA GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA click arrow to show/hide IEA associations GO:0045087 innate immune response IEA

Immuno Process:  T cell (activation) GO Annotations:  Associated to 2 GO processes GO:0042102 positive regulation of T cell proliferation IMP click arrow to show/hide IEA associations GO:0002250 adaptive immune response IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 2 GO processes GO:0042102 positive regulation of T cell proliferation IMP GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 1 GO processes GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 1 GO processes GO:0042102 positive regulation of T cell proliferation IMP

Immuno Process:  Cellular signalling GO Annotations:  Associated to 2 GO processes GO:0001771 immunological synapse formation IMP GO:0042102 positive regulation of T cell proliferation IMP

Immuno Process:  Antigen presentation GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0005044 scavenger receptor activity IEA

Immuno Process:  B cell (activation) GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0002250 adaptive immune response IEA

Immuno Disease Associations

Disease Name:  Psoriasis Disease Synonyms:  no synonynms Comment:  CD6 is the molecular target of itolizumab, a drug approved for the treatment of chronic plaque psoriasis. Disease X-refs:  Disease Ontology: DOID:8893 References: