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CD6

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2917

Nomenclature: CD6

Family: CD molecules

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 668 11q12.2 CD6 CD6 molecule
Mouse 1 665 19 7.16 cM Cd6 CD6 antigen
Rat - 665 1q43 Cd6 Cd6 molecule
Gene and Protein Information Comments
Details of alternate transcripts and protein isoforms identified for human and mouse CD6 are available from their NCBI (Entrez) gene entries.
Previous and Unofficial Names Click here for help
Tp120
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
itolizumab Peptide Approved drug Primary target of this compound Immunopharmacology Ligand Hs Binding 7.2 pKi 1
pKi 7.2 (Ki 6x10-8 M) [1]
Immunopharmacology Comments
CD6 is a co-stimulatory molecule, predominantly expressed on lymphocytes and associated with autoimmune responses. CD6 interacts with activated leucocyte-cell adhesion molecule (ALCAM/CD166), found on antigen presenting cells. This interaction induces the production of proinflammatory cytokines [2], prostaglandins, leukotrienes and oxygen free radicals.
Druggability is indicated by approval of the anti-CD6 monoclonal antibody itolizumab to treat psoriasis.
Cell Type Associations
Immuno Cell Type:  T cells
Immuno Cell Type:  B cells
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  T cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Chemotaxis & migration
Immuno Process:  Cellular signalling
Immuno Process:  Antigen presentation
Immuno Process:  B cell (activation)
Immuno Disease Associations
Disease Name:  Psoriasis
Disease Synonyms:  no synonynms
Comment:  CD6 is the molecular target of itolizumab, a drug approved for the treatment of chronic plaque psoriasis.
Disease X-refs:  Disease Ontology: DOID:8893
References: 

References

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1. Alonso R, Huerta V, de Leon J, Piedra P, Puchades Y, Guirola O, Chinea G, Montero E. (2008) Towards the definition of a chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody. Hybridoma (Larchmt), 27 (4): 291-301. [PMID:18707547]

2. Nair P, Melarkode R, Rajkumar D, Montero E. (2010) CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction. Clin Exp Immunol, 162 (1): 116-30. [PMID:20726988]

How to cite this page

CD molecules: CD6. Last modified on 06/02/2017. Accessed on 14/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2917.