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DExH-box helicase 58

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2922

Nomenclature: DExH-box helicase 58

Abbreviated Name: LGP2

Family: RIG-I-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 678 17q21.2 DHX58 DExH-box helicase 58
Mouse - 678 11 D; 11 63.52 cM Dhx58 DExH-box helicase 58
Rat - 678 10q31 Dhx58 DEXH-box helicase 58
Previous and Unofficial Names Click here for help
DEXH (Asp-Glu-X-His) box polypeptide 58 | RNA helicase LGP2
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:
Description Reaction Reference
RNA helicase: uses the energy from ATP hydrolysis to unwind RNA ATP + H(2)O <=> ADP + phosphate
Immunopharmacology Comments
LGP2 binds RNA but does not participate in the signaling pathway that RIG-1 and MDA5 are part of, and is assumed to provide a negative feedback for IFNβ induction by sequestering pathogen-derived RNA.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling

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