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Targets Associated to Immuno Processes - Tissue repair

Jump to: GPCR | Ion Channels | Enzymes | Other Protein Targets |

Tissue repair
GPCRs
GtoPdb receptor name (family) Process Association Comments GO Associations Immunopharmacology Comments
CCR2
(Chemokine receptors)
  • wound healing involved in inflammatory response (GO:0002246) NAS
  • inflammatory response to wounding (GO:0090594) ISS
CCR2 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation. CCR2 is discussed in relation to immuno-oncology in [1] ...
PAR1
(Proteinase-activated receptors)
  • connective tissue replacement involved in inflammatory response wound healing (GO:0002248) IDA
PAR1 has been found to mediate the effects of neutrophil elastase (NE) on γδ T cell activation, as the PAR1 inhibitor abrogates NE (from neutrophils)-induced activation of these T cells [33] ...
Ion Channels
GtoPdb receptor name (family) Process Association Comments GO Associations Immunopharmacology Comments
P2X5
(P2X receptors)
  • regulation of skeletal muscle tissue regeneration (GO:0043416) ISO
P2X ligand-gated ion channels elicit pro-inflammatory immune responses upon activation by extracellular ATP that acts as a DAMP when released from damaged or infected cells [9-10] ...
Enzymes
GtoPdb receptor name (family) Process Association Comments GO Associations Immunopharmacology Comments
enhancer of zeste 2 polycomb repressive complex 2 subunit
(2.1.1.43 Histone methyltransferases (HMTs))
  • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration (GO:0014834) IEA
EZH2 is involved in hematopoietic stem cell proliferation and differentiation, thymopoiesis and lymphopoiesis, with notable participation in regulating the differentiation and function of T cells. This role suggests potential applications in immune-mediated conditions, including autoimmune disorders [34] ...
Haem oxygenase 1
(Haem oxygenase)
  • wound healing involved in inflammatory response (GO:0002246) IMP
Heme oxygenase (HO) is a rate-limiting enzyme in the catabolism of heme, catalyzing the oxidative cleavage of heme (Fe-protoporphyrin-IX) to render equimolar amounts of biliverdin, ferrous iron (Fe2+), and carbon monoxide (CO).

Heme oxygenase 1 (HO1) is a Nrf2-regulated gene, whose expression is upregulated as a cytoprotective mechanism in response to cellular stresses including inflammation, ischemia, hypoxia, hyperoxia, hyperthermia, or radiation.

HO1 has antioxidant, antiinflammatory, antiapoptotic, antiproliferative, and immunomodulatory effects in vascular cells, playing an important role in the prevention of vascular inflammation and atherogenesis (reviewed in [3] ...
mitogen-activated protein kinase 14
(p38 subfamily)
  • myoblast differentiation involved in skeletal muscle regeneration (GO:0014835) IMP
p38 MAP kinases are ubiquitous, highly conserved enzymes which regulate the production of proinflammatory mediators (such as TNFα and IL-1) in response to inflammatory cytokines or environmental stress [12-13,19,25,27,38] ...
protein kinase C theta
(Delta subfamily)
  • tissue regeneration (GO:0042246) IEP
PKC-θ is a novel subfamily PKC found predominantly in hematopoietic cells [4] ...
tec protein tyrosine kinase
(Tec family)
  • tissue regeneration (GO:0042246) IBA
The TEC family protein tyrosine kinases have been identified as key components of T-cell-receptor activation and signalling. TEC family kinases are expressed predominantly by haematopoietic cells. T cells express ITK, TXK and TEC [6] ...
Other Protein Targets
GtoPdb receptor name (family) Process Association Comments GO Associations Immunopharmacology Comments
advanced glycosylation end-product specific receptor
(Immunoglobulin like domain containing proteins)
  • negative regulation of connective tissue replacement involved in inflammatory response wound healing (GO:1904597) IEA
RAGE is a single chain, membrane bound immunoglobulin type protein [24,30,42] ...
notch receptor 1
(Notch receptors)
  • tissue regeneration (GO:0042246) IEA
Activating mutations in NOTCH1 are one of the most frequent somatic alterations detected in chronic lymphocytic leukemia (CLL), and such mutations are associated with poor prognosis [26,29,35] ...