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sialic acid binding Ig like lectin 10

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 3169

Nomenclature: sialic acid binding Ig like lectin 10

Abbreviated Name: SIGLEC10

Family: Sialic acid binding Ig like lectins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 697 19q13.41 SIGLEC10 sialic acid binding Ig like lectin 10
Mouse 1 688 7 B3 Siglecg sialic acid binding Ig-like lectin G
Rat 1 372 1q22 Siglec10 sialic acid binding Ig-like lectin 10
Database Links Click here for help
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

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Agonists
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Ligand Sp. Action Value Parameter Reference
MK-7110 Peptide Immunopharmacology Ligand Hs Agonist - - 3
[3]
Immunopharmacology Comments
Siglec-10 is an inhibitory co-receptor that is expressed by cells of the innate immune system. Its interaction with CD24 reduces the T cell response to danger-associated molecular patterns (DAMPs) [2]. Use of a synthetic CD24 mimetic has been shown to reduce tissue damage-induced immune responses [1].
Immuno Process Associations
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0002250 adaptive immune response IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0002250 adaptive immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0106015 negative regulation of inflammatory response to wounding IPI
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0106015 negative regulation of inflammatory response to wounding IPI
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GO:0045087 innate immune response IEA
Immuno Process:  Tissue repair
GO Annotations:  Associated to 1 GO processes
GO:0106015 negative regulation of inflammatory response to wounding IPI

References

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1. Chen GY, Tang J, Zheng P, Liu Y. (2009) CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science, 323 (5922): 1722-5. [PMID:19264983]

2. Toubai T, Rossi C, Oravecz-Wilson K, Zajac C, Liu C, Braun T, Fujiwara H, Wu J, Sun Y, Brabbs S et al.. (2017) Siglec-G represses DAMP-mediated effects on T cells. JCI Insight, 2 (14). [PMID:28724800]

3. Zheng X, Wu W, Liu Y, Zheng P. (2013) Methods of use of soluble cd24 for therapy of rheumatoid arthritis. Patent number: US20130231464A1. Assignee: Oncolmmune, Inc.. Priority date: 28/04/2010. Publication date: 05/09/2013.

How to cite this page

Sialic acid binding Ig like lectins: sialic acid binding Ig like lectin 10. Last modified on 28/01/2021. Accessed on 01/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3169.