Sialic acid binding Ig like lectins

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Sialic acid binding Ig like lectins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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SIGLECs are a family of type I transmembrane proteins that are predominantly expressed by hemopoietic cells and they play critical roles in immune cell signalling and discrimination of self and nonself. The SIGLECs act as checkpoints in immune responses in human diseases including cancer, asthma, allergy, neurodegeneration, and autoimmune diseases and are being investigated as therapeutic targets [3-4].

Targets

SIGLEC2 (CD22) Show summary »« Hide summary More detailed page

Target Id	2786
Nomenclature	CD22
Common abbreviation	SIGLEC2
Previous and unofficial names	B-lymphocyte cell adhesion molecule \| sialic acid binding Ig-like lectin 2 \| SIGLEC-2
Genes	CD22 (Hs)
Ensembl ID	ENSG00000012124 (Hs)
UniProtKB AC	P20273 (Hs)

SIGLEC3 (CD33) C Show summary »« Hide summary More detailed page

SIGLEC8 (sialic acid binding Ig like lectin 8) Show summary »« Hide summary More detailed page

Target Id	3012
Nomenclature	sialic acid binding Ig like lectin 8
Common abbreviation	SIGLEC8
Previous and unofficial names	SAF2 \| SIGLEC-8 \| SIGLEC8L
Genes	SIGLEC8 (Hs), Siglecf (Mm), Siglec8 (Rn)
Ensembl ID	ENSG00000105366 (Hs), ENSMUSG00000039013 (Mm)
UniProtKB AC	Q9NYZ4 (Hs), Q920G3 (Mm)

References

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1. Bernstein ID. (2000) Monoclonal antibodies to the myeloid stem cells: therapeutic implications of CMA-676, a humanized anti-CD33 antibody calicheamicin conjugate. Leukemia, 14 (3): 474-5. [PMID:10720144]

2. Caron PC, Co MS, Bull MK, Avdalovic NM, Queen C, Scheinberg DA. (1992) Biological and immunological features of humanized M195 (anti-CD33) monoclonal antibodies. Cancer Res., 52 (24): 6761-7. [PMID:1458463]

3. Duan S, Paulson JC. (2020) Siglecs as Immune Cell Checkpoints in Disease. Annu. Rev. Immunol., 38: 365-395. [PMID:31986070]

4. Gibbons A. (2020) How an ancient microbial arms race remodeled human cells. Science, 369 (6503): 491-492. [PMID:32732402]

How to cite this family page

Database page citation:

Sialic acid binding Ig like lectins. Accessed on 27/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1000.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.