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CD33-related SIGLECs

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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CD33-related SIGLECs (3, 5, 6, 7, 8, 9, 10, 11, 12, 14, and 16) are more broadly expressed in myeloid and lymphoid tissues and cells than the conserved SIGLECs. The structurally and functionally related SIGLECs 7 and 9 from this subfamily [10] have been implicated in myeloid cell-mediated modulation in cancer [1-2,5-8], making these proteins novel therapeutic targets to enhance antitumour immunity (cancer immunotherapy).

Targets

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SIGLEC3 (CD33) C Show summary » More detailed page go icon to follow link

SIGLEC8 (sialic acid binding Ig like lectin 8) Show summary » More detailed page go icon to follow link

SIGLEC10 (sialic acid binding Ig like lectin 10) Show summary » More detailed page go icon to follow link

Further reading

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References

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How to cite this family page

Database page citation:

CD33-related SIGLECs. Accessed on 21/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1000.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.