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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
SIGLECs are a family of type I transmembrane proteins that are predominantly expressed by hemopoietic cells and they play critical roles in immune cell signalling and discrimination of self and nonself. The SIGLECs act as checkpoints in immune responses in human diseases including cancer, asthma, allergy, neurodegeneration, and autoimmune diseases and are being investigated as therapeutic targets [3-4].
SIGLEC2 (CD22)
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SIGLEC3 (CD33)
C
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SIGLEC8 (sialic acid binding Ig like lectin 8)
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Database page citation:
Sialic acid binding Ig like lectins. Accessed on 23/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1000.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.