Sialic acid binding Ig like lectins (SIGLECS)

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Sialic acid binding Ig like lectins (SIGLECS)

Overview
Subfamilies
References
How to cite this family page

Overview

SIGLECs are a family of type I transmembrane proteins (15 in humans) that are predominantly expressed by hemopoietic cells and they play critical roles in immune cell signalling and discrimination of self and nonself. The receptors differ in their specificity for sialic acid containing ligands. SIGLECs act as checkpoints in immune responses in human diseases including cancer, asthma, allergy, neurodegeneration, and autoimmune diseases and are being investigated as therapeutic targets [1-3].

Subfamilies

References

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1. Boelaars K, van Kooyk Y. (2024) Targeting myeloid cells for cancer immunotherapy: Siglec-7/9/10/15 and their ligands. Trends Cancer, 10 (3): 230-241. [PMID:38160071]

2. Duan S, Paulson JC. (2020) Siglecs as Immune Cell Checkpoints in Disease. Annu Rev Immunol, 38: 365-395. [PMID:31986070]

3. Gibbons A. (2020) How an ancient microbial arms race remodeled human cells. Science, 369 (6503): 491-492. [PMID:32732402]

How to cite this family page

Database page citation:

Sialic acid binding Ig like lectins (SIGLECS). Accessed on 27/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1093.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.