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Target not currently curated in GtoImmuPdb

Target id: 779

Nomenclature: ABCC1

Abbreviated Name: MRP1

Systematic Nomenclature: ABCC1

Family: ABCC subfamily

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 17 1531 16p13.1 ABCC1 ATP binding cassette subfamily C member 1
Mouse 17 1528 16 9.75 cM Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Rat 17 1532 10q11 Abcc1 ATP binding cassette subfamily C member 1
Previous and Unofficial Names
leukotriene C4 transporter | GS-X | MRP | multidrug resistance associated protein 1 | Abcc1a | ATP-binding cassette sub-family C (CFTR/MRP) member 1 (multiple drug resistance-associated protein) | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1a | Avcc1a | LTC4 transporter | Multidrug resistance protein 1 | Abcc1b | Mdrap | ATP-binding cassette sub-family C (CFTR/MRP) member 1a | MRP1 | ATP-binding cassette, subfamily C (CFTR/MRP), member 1 | ATP-binding cassette
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Structure of the human multidrug resistance protein 1 nucleotide binding domain 1
Resolution:  1.5Å
Species:  Human
References:  2

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
WP814 Hs Inhibition 7.2 pKi 1
pKi 7.2 (Ki 7x10-8 M) [1]
compound 14 [PMID: 30925062] Hs Competitive 5.3 pIC50 3
pIC50 5.3 (IC50 5.04x10-6 M) [3]
Description: Measuring inhibition of calcein AM transport in H69AR cells overexpressing hABCC1.


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1. Priebe W, Krawczyk M, Kuo MT, Yamane Y, Savaraj N, Ishikawa T. (1998) Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. Biochem. Biophys. Res. Commun., 247 (3): 859-63. [PMID:9647783]

2. Ramaen O, Leulliot N, Sizun C, Ulryck N, Pamlard O, Lallemand JY, Tilbeurgh Hv, Jacquet E. (2006) Structure of the human multidrug resistance protein 1 nucleotide binding domain 1 bound to Mg2+/ATP reveals a non-productive catalytic site. J. Mol. Biol., 359 (4): 940-9. [PMID:16697012]

3. Silbermann K, Stefan SM, Elshawadfy R, Namasivayam V, Wiese M. (2019) Identification of Thienopyrimidine Scaffold as an Inhibitor of the ABC Transport Protein ABCC1 (MRP1) and Related Transporters Using a Combined Virtual Screening Approach. J. Med. Chem., 62 (9): 4383-4400. [PMID:30925062]


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