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Interleukin-13 receptor subunit α1

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1700

Nomenclature: Interleukin-13 receptor subunit α1

Family: IL-2 receptor family

Quaternary Structure: Complexes
Interleukin-4 receptor type II
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 427 Xq24 IL13RA1 interleukin 13 receptor subunit alpha 1
Mouse 1 424 X 20.49 cM Il13ra1 interleukin 13 receptor, alpha 1
Rat - - Il13ra1 interleukin 13 receptor subunit alpha 1
Previous and Unofficial Names Click here for help
CD213a1 | NR4 | IL13 receptor alpha-1 chain | interleukin 13 receptor, alpha 1 | interleukin 13 receptor
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
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Antibody Sp. Action Value Parameter Reference
eblasakimab Peptide Hs Binding 10.6 pKd 1
pKd 10.6 (Kd 2.7x10-11 M) [1]
Description: Binding affinity of full-length antibody 10G5-6 for hIL13Rα1, determined by proprietary KINEXA assay.
Immunopharmacology Comments
Interleukin-13 receptor subunit α1 is a component of the functional receptors that mediate the pro-inflammatory actions of the cytokines IL-4 and IL-13.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 5 GO processes, IEA only
GO:0004896 cytokine receptor activity IBA
GO:0004923 leukemia inhibitory factor receptor activity IBA
GO:0016515 interleukin-13 receptor activity IBA
GO:0019221 cytokine-mediated signaling pathway TAS
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GO:0038165 oncostatin-M-mediated signaling pathway IEA

References

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1. Nash AD, Andrews AE, Baca M, Edwarda KM, Hardt MP, Panousis C, Dunlop FM. (2012) Antibodies against g-csfr and uses thereof. Patent number: WO2012171057A1. Assignee: Csl Limited. Priority date: 13/06/2011. Publication date: 20/12/2012.

How to cite this page

IL-2 receptor family: Interleukin-13 receptor subunit α1. Last modified on 22/10/2021. Accessed on 01/10/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1700.