Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	209	12p13.31	CLEC6A	C-type lectin domain containing 6A
Mouse	1	209	6 58.3 cM	Clec4n	C-type lectin domain family 4, member n
Gene and Protein Information Comments
A shorter transcript and protein isoform of human the CLEC6A gene have been reported [1]. Two alternative transcripts and protein isoforms arising from the mouse gene have been identified. A rat homolog of human CLEC6A has not been identified.

Previous and Unofficial Names

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10 | CLECSF10 | CLEC4N | C-type lectin domain family 4, member n | C-type lectin domain family 4

Database Links
Alphafold	Q6EIG7 (Hs), Q9JKF4 (Mm)
CATH/Gene3D	3.10.100.10
ChEMBL Target	CHEMBL2176856 (Hs)
Ensembl Gene	ENSG00000205846 (Hs), ENSMUSG00000023349 (Mm)
Entrez Gene	93978 (Hs), 56620 (Mm)
Human Protein Atlas	ENSG00000205846 (Hs)
KEGG Gene	hsa:93978 (Hs), mmu:56620 (Mm)
OMIM	613579 (Hs)
Pharos	Q6EIG7 (Hs)
RefSeq Nucleotide	NM_001007033 (Hs), NM_020001 (Mm)
RefSeq Protein	NP_001007034 (Hs), NP_064385 (Mm)
UniProtKB	Q6EIG7 (Hs), Q9JKF4 (Mm)
Wikipedia	CLEC6A (Hs)

Immunopharmacology Comments

Dectin-2 is involved in initiating the innate immune response upon recognition of high mannose structures on fungal cell walls. It associates with the ITAM-containing FcRβ adaptor and signals through the Syk, PKCδ, and CARD9-Bcl10-MALT1 pathways to promote cytokine production in response to fungal infection.

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Cytokine production & signalling

Immuno Process:  Cellular signalling

Immuno Process:  T cell (activation)

Immuno Process:  B cell (activation)

General Comments
Dectin-2 is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).