Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	343	1q23.1-q23.2	AIM2	absent in melanoma 2
Mouse	-	354	1 H3	Aim2	absent in melanoma 2
Rat	-	356	13q24	Aim2	absent in melanoma 2
Gene and Protein Information Comments
The human gene has a second reported splice variant generating a shorter protein isofom, with a shorter N-terminus (238 amino acids).

Previous and Unofficial Names

interferon-inducible protein AIM2 | PYHIN4

Database Links
Alphafold	O14862 (Hs), Q91VJ1 (Mm)
ChEMBL Target	CHEMBL4630802 (Hs), CHEMBL4295911 (Mm)
Ensembl Gene	ENSG00000163568 (Hs), ENSMUSG00000037860 (Mm), ENSRNOG00000003480 (Rn)
Entrez Gene	9447 (Hs), 383619 (Mm), 304987 (Rn)
Human Protein Atlas	ENSG00000163568 (Hs)
KEGG Gene	hsa:9447 (Hs), mmu:383619 (Mm), rno:304987 (Rn)
OMIM	604578 (Hs)
Pharos	O14862 (Hs)
RefSeq Nucleotide	NM_004833 (Hs), NM_001013779 (Mm)
RefSeq Protein	NP_004824 (Hs), NP_001013801 (Mm)
UniProtKB	O14862 (Hs), Q91VJ1 (Mm)
Wikipedia	AIM2 (Hs)

Immunopharmacology Comments

AIM2 primarily senses cytosolic DNA and initiates formation of an inflammasome to drive IL-1β cleavage and secretion.

Immuno Process Associations

Immuno Process:  Cellular signalling GO Annotations:  Associated to 1 GO processes GO:0002221 pattern recognition receptor signaling pathway NAS

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 3 GO processes GO:0032731 positive regulation of interleukin-1 beta production IDA GO:0033209 tumor necrosis factor-mediated signaling pathway IDA GO:0035458 cellular response to interferon-beta IBA

Immuno Process:  Immune regulation GO Annotations:  Associated to 4 GO processes GO:0002218 activation of innate immune response IDA GO:0002221 pattern recognition receptor signaling pathway NAS GO:0043029 T cell homeostasis ISS GO:0050729 positive regulation of inflammatory response NAS

Immuno Process:  Inflammation GO Annotations:  Associated to 5 GO processes GO:0002218 activation of innate immune response IDA GO:0002221 pattern recognition receptor signaling pathway NAS GO:0038187 pattern recognition receptor activity IDA GO:0050729 positive regulation of inflammatory response NAS click arrow to show/hide IEA associations GO:0045087 innate immune response IEA

General Comments
AIM2 is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family (HGNC family 995) [1].