Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	343	1q23.1-q23.2	AIM2	absent in melanoma 2
Mouse	-	354	1 H3	Aim2	absent in melanoma 2
Rat	-	356	13q24	Aim2	absent in melanoma 2
Gene and Protein Information Comments
The human gene has a second reported splice variant generating a shorter protein isofom, with a shorter N-terminus (238 amino acids).

Previous and Unofficial Names

interferon-inducible protein AIM2 | PYHIN4

Database Links
Alphafold	O14862 (Hs), Q91VJ1 (Mm)
ChEMBL Target	CHEMBL4630802 (Hs), CHEMBL4295911 (Mm)
Ensembl Gene	ENSG00000163568 (Hs), ENSMUSG00000037860 (Mm), ENSRNOG00000003480 (Rn)
Entrez Gene	9447 (Hs), 383619 (Mm), 304987 (Rn)
Human Protein Atlas	ENSG00000163568 (Hs)
KEGG Gene	hsa:9447 (Hs), mmu:383619 (Mm), rno:304987 (Rn)
OMIM	604578 (Hs)
Pharos	O14862 (Hs)
RefSeq Nucleotide	NM_004833 (Hs), NM_001013779 (Mm)
RefSeq Protein	NP_004824 (Hs), NP_001013801 (Mm)
UniProtKB	O14862 (Hs), Q91VJ1 (Mm)
Wikipedia	AIM2 (Hs)

Immunopharmacology Comments

AIM2 primarily senses cytosolic DNA and initiates formation of an inflammasome to drive IL-1β cleavage and secretion.

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Cytokine production & signalling

General Comments
AIM2 is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family (HGNC family 995) [1].