absent in melanoma 2 | Absent in melanoma (AIM)-like receptors (ALRs) | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

absent in melanoma 2

target has curated data in GtoImmuPdb

Target id: 2923

Nomenclature: absent in melanoma 2

Abbreviated Name: AIM2

Family: Absent in melanoma (AIM)-like receptors (ALRs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 343 1q23.1-q23.2 AIM2 absent in melanoma 2
Mouse - 354 C1, 80.33 cM Aim2 absent in melanoma 2
Rat - 356 13q24 Aim2 absent in melanoma 2
Gene and Protein Information Comments
The human gene has a second reported splice variant generating a shorter protein isofom, with a shorter N-terminus (238 amino acids).
Previous and Unofficial Names
interferon-inducible protein AIM2 | PYHIN4
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Immunopharmacology Comments
AIM2 primarily senses cytosolic DNA and initiates formation of an inflammasome to drive IL-1β cleavage and secretion.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002218 activation of innate immune response IDA
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0002218 activation of innate immune response IDA
GO:0002230 positive regulation of defense response to virus by host ISS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 5 GO processes
GO:0032731 positive regulation of interleukin-1 beta production IDA
GO:0033209 tumor necrosis factor-mediated signaling pathway IDA
GO:0050702 interleukin-1 beta secretion IMP
GO:0050718 positive regulation of interleukin-1 beta secretion IDA
click arrow to show/hide IEA associations
GO:0035458 cellular response to interferon-beta IEA
General Comments
AIM2 is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family (HGNC family 995) [1].


Show »

1. Schattgen SA, Fitzgerald KA. (2011) The PYHIN protein family as mediators of host defenses. Immunol. Rev., 243 (1): 109-18. [PMID:21884171]

How to cite this page

Absent in melanoma (AIM)-like receptors (ALRs): absent in melanoma 2. Last modified on 03/03/2017. Accessed on 07/06/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2923.