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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1782

Nomenclature: NLRC4

Family: NOD-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1024 2p22.3 NLRC4 NLR family CARD domain containing 4
Mouse - 1024 17 E2 Nlrc4 NLR family, CARD domain containing 4
Rat - 1023 6q13 Nlrc4 NLR family, CARD domain containing 4
Previous and Unofficial Names Click here for help
NOD4 | caspase recruitment domain family, member 12 | NOD-like receptor C4 | NLR family, CARD domain containing 4 | CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | NLR family | IPAF
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
As part of the innate inflammatory response to invading mobile bacteria, NLRC4 (Ipaf) in macrophages induces a pro-inflammatory response upon detection of cytosolic bacterial flagellin. In contrast, extracellular bacterial flagellin is detected by TLR5 [1].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Physiological Functions Comments
Involved in inflammasome formation and caspase-1 activation. Co-operates with NAIP proteins to form an inflammasome.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Autoinflammation with infantile enterocolitis; AIFEC
OMIM: 616050
Disease:  Familial cold autoinflammatory syndrome 4; FCAS4
OMIM: 616115


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1. Miao EA, Andersen-Nissen E, Warren SE, Aderem A. (2007) TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. Semin Immunopathol, 29 (3): 275-88. [PMID:17690885]


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