NLRC4 | NOD-like receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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target has curated data in GtoImmuPdb

Target id: 1782

Nomenclature: NLRC4

Family: NOD-like receptor family

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1024 2p22.3 NLRC4 NLR family CARD domain containing 4
Mouse - 1024 17 45.64 cM Nlrc4 NLR family
Rat - 1023 6 q12 Nlrc4 NLR family
Previous and Unofficial Names
NOD4 | caspase recruitment domain family, member 12 | NOD-like receptor C4 | NLR family, CARD domain containing 4 | CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAF | NLR family
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Immunopharmacology Comments
As part of the innate inflammatory response to invading mobile bacteria, NLRC4 (Ipaf) in macrophages induces a pro-inflammatory response upon detection of cytosolic bacterial flagellin. In contrast, extracellular bacterial flagellin is detected by TLR5 [1].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002218 activation of innate immune response ISS
GO:0006954 inflammatory response ISS
click arrow to show/hide IEA associations
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0002218 activation of innate immune response ISS
Immuno Process:  Cytokine production & signalling
Physiological Functions Comments
Involved in inflammasome formation and caspase-1 activation. Co-operates with NAIP proteins to form an inflammasome.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Autoinflammation with infantile enterocolitis; AIFEC
OMIM: 616050
Disease:  Familial cold autoinflammatory syndrome 4; FCAS4
OMIM: 616115


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1. Miao EA, Andersen-Nissen E, Warren SE, Aderem A. (2007) TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. Semin Immunopathol, 29 (3): 275-88. [PMID:17690885]


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