Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	724	6p21.1	HSP90AB1	heat shock protein 90 alpha family class B member 1
Mouse	-	724	17 22.59 cM	Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1
Rat	-	724	9q12	Hsp90ab1	heat shock protein 90 alpha family class B member 1

Previous and Unofficial Names

HSP90AB1 | HSp90AB1 | heat shock protein 90 alpha (cytosolic), class B member 1 | heat shock protein 90 alpha (cytosolic)

Database Links
Alphafold	P08238 (Hs), P11499 (Mm), P34058 (Rn)
CATH/Gene3D	3.30.565.10
ChEMBL Target	CHEMBL4303 (Hs)
Ensembl Gene	ENSG00000096384 (Hs), ENSMUSG00000023944 (Mm), ENSRNOG00000019834 (Rn)
Entrez Gene	3326 (Hs), 15516 (Mm), 301252 (Rn)
Human Protein Atlas	ENSG00000096384 (Hs)
KEGG Gene	hsa:3326 (Hs), mmu:15516 (Mm), rno:301252 (Rn)
Pharos	P08238 (Hs)
RefSeq Nucleotide	NM_007355 (Hs), NM_008302 (Mm), NM_001004082 (Rn)
RefSeq Protein	NP_031381 (Hs), NP_032328 (Mm), NP_001004082 (Rn)
UniProtKB	P08238 (Hs), P11499 (Mm), P34058 (Rn)
Wikipedia	HSP90AB1 (Hs)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference luminespib Hs Inhibition 8.7 pIC50 ⤷ pIC50 8.7 (IC50 2x10-9 M) geldanamycin Hs Inhibition 6.6 pIC50 2 ⤷ pIC50 6.6 (IC50 2.82x10-7 M) [2]

Immunopharmacology Comments

HSP90AB1 chaperones both JAK2 and PRKCE, and by ensuring proper folding of these kinase proteins it is involved in the phosphorylation/activation of STAT1 [1]. This tangential function in JAK/STAT signalling indicates a potential role for HSP90AB1 in inflammation and the immune response.