death receptor 3 | Tumour necrosis factor (TNF) receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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death receptor 3

target has curated data in GtoImmuPdb

Target id: 1883

Nomenclature: death receptor 3

Abbreviated Name: DR3

Systematic Nomenclature: TNFRSF25

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 417 01p36.31 TNFRSF25 TNF receptor superfamily member 25
Mouse - - Tnfrsf25 tumor necrosis factor receptor superfamily, member 25
Rat - - Tnfrsf25 TNF receptor superfamily member 25
Previous and Unofficial Names
apoptosis-mediating receptor DR3 | apoptosis-mediating receptor TRAMP | death domain receptor 3 | WSL-1 | WSL-LR | tumor necrosis factor receptor superfamily, member 25 | APO-3 | DDR3 | TNFRSF12 | TR3 | tumor necrosis factor receptor superfamily
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
Natural/Endogenous Ligands
TL1A {Sp: Human}
Adaptor proteins (Human)
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
TL1A {Sp: Human} Hs - - -
Immunopharmacology Comments
In the absence of any other exogenous signals, activation of DR3 causes proliferation of FoxP3+ regulatory T cells [1].
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0005031 tumor necrosis factor-activated receptor activity TAS
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS


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1. Schreiber TH, Wolf D, Tsai MS, Chirinos J, Deyev VV, Gonzalez L, Malek TR, Levy RB, Podack ER. (2010) Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. J. Clin. Invest., 120 (10): 3629-40. [PMID:20890040]


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