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death receptor 3

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1883

Nomenclature: death receptor 3

Abbreviated Name: DR3

Systematic Nomenclature: TNFRSF25

Family: Tumour necrosis factor (TNF) receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 417 1p36.31 TNFRSF25 TNF receptor superfamily member 25
Mouse - - Tnfrsf25 tumor necrosis factor receptor superfamily, member 25
Rat - - Tnfrsf25 TNF receptor superfamily member 25
Previous and Unofficial Names Click here for help
apoptosis-mediating receptor DR3 | apoptosis-mediating receptor TRAMP | death domain receptor 3 | WSL-1 | WSL-LR | tumor necrosis factor receptor superfamily, member 25 | APO-3 | DDR3 | TNFRSF12 | TR3 | tumor necrosis factor receptor superfamily
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
Natural/Endogenous Ligands Click here for help
TL1A {Sp: Human}
Adaptor proteins (Human)
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
TL1A {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs - - -
Immunopharmacology Comments
In the absence of any other exogenous signals, activation of DR3 causes proliferation of FoxP3+ regulatory T cells [1].
Immuno Process Associations
Immuno Process:  Cytokine production & signalling


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1. Schreiber TH, Wolf D, Tsai MS, Chirinos J, Deyev VV, Gonzalez L, Malek TR, Levy RB, Podack ER. (2010) Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. J Clin Invest, 120 (10): 3629-40. [PMID:20890040]


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