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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 329 | 3q13.33 | CD86 | CD86 molecule | |
Mouse | 1 | 309 | 16 25.72 cM | Cd86 | CD86 antigen | |
Rat | - | 313 | 11q22 | Cd86 | CD86 molecule |
Previous and Unofficial Names |
CD86 antigen |
Database Links | |
Alphafold | P42081 (Hs), P42082 (Mm) |
CATH/Gene3D | 2.60.40.10 |
ChEMBL Target | CHEMBL2364156 (Hs) |
DrugBank Target | P42081 (Hs) |
Ensembl Gene | ENSG00000114013 (Hs), ENSMUSG00000022901 (Mm), ENSRNOG00000038835 (Rn) |
Entrez Gene | 942 (Hs), 12524 (Mm), 56822 (Rn) |
Human Protein Atlas | ENSG00000114013 (Hs) |
KEGG Gene | hsa:942 (Hs), mmu:12524 (Mm), rno:56822 (Rn) |
OMIM | 601020 (Hs) |
Pharos | P42081 (Hs) |
RefSeq Nucleotide | NM_175862 (Hs), NM_019388 (Mm), NM_020081 (Rn) |
RefSeq Protein | NP_787058 (Hs), NP_062261 (Mm), NP_064466 (Rn) |
UniProtKB | P42081 (Hs), P42082 (Mm) |
Wikipedia | CD86 (Hs) |
Immunopharmacology Comments |
CD86 (B7-2) is a type I membrane immunoglobulin. It is expressed on antigen-presenting cells and in association with CD80 provides the costimulatory signal necessary for T cell activation and survival. CD86 interacts with CD28 or CTLA-4 on T cells. It is the interaction with CTLA-4 that is targeted by the approved immunosuppresive drugs abatacept and belatacept. |
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Immuno Disease Associations | ||||||||||
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General Comments |
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590. |
1. Latek R, Fleener C, Lamian V, Kulbokas 3rd E, Davis PM, Suchard SJ, Curran M, Vincenti F, Townsend R. (2009) Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation. Transplantation, 87 (6): 926-33. [PMID:19300198]
2. Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA. (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med, 174 (3): 561-9. [PMID:1714933]
3. Vicente Rabaneda EF, Herrero-Beaumont G, Castañeda S. (2013) Update on the use of abatacept for the treatment of rheumatoid arthritis. Expert Rev Clin Immunol, 9 (7): 599-621. [PMID:23899231]
Other immune checkpoint proteins: CD86. Last modified on 28/06/2022. Accessed on 09/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2745.