Ligand id: 8417

Name: GLPG0974

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 106.16
Molecular weight 484.12
XLogP 4.17
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
A Phase II clinical trial evaluating GLPG0974 in ulcerative colitis has been completed (NCT01829321). Safety, pharmacokinetics and pharmacodynamics of GLPG0974 in healthy subjects are reported in [2].