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Interleukin-11 receptor, α subunit

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1709

Nomenclature: Interleukin-11 receptor, α subunit

Family: IL-6 receptor family

Quaternary Structure: Complexes
Interleukin-11 receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 422 9p13.3 IL11RA interleukin 11 receptor subunit alpha
Mouse 1 432 4 21.94 cM Il11ra1 interleukin 11 receptor subunit alpha 1
Rat 1 431 5q22 Il11ra1 interleukin 11 receptor subunit alpha 1
Previous and Unofficial Names Click here for help
Il11ra | NR1 | interleukin 11 receptor, alpha | interleukin 11 receptor
Database Links Click here for help
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Agonist Comments
Interleukin-11 receptor, α subunit is the primary target of the approved drug oprelvekin, a recombinant form of IL-11.
Immunopharmacology Comments
This is the ligand-binding component of the functional receptor for interleukin 11.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling
Immuno Process:  Immune system development
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Craniosynostosis and dental anomalies
OMIM: 614188
Orphanet: ORPHA284149

How to cite this page

IL-6 receptor family: Interleukin-11 receptor, α subunit. Last modified on 07/04/2017. Accessed on 29/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,