Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	836	1p34.3	CSF3R	colony stimulating factor 3 receptor
Mouse	1	837	4 59.77 cM	Csf3r	colony stimulating factor 3 receptor
Rat	-	-	5q36	Csf3r	colony stimulating factor 3 receptor

Previous and Unofficial Names

CD114 | granulocyte colony-stimulating factor receptor | GCSFR

Database Links
Alphafold	Q99062 (Hs), P40223 (Mm)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL1996 (Hs)
DrugBank Target	Q99062 (Hs)
Ensembl Gene	ENSG00000119535 (Hs), ENSMUSG00000028859 (Mm), ENSRNOG00000008759 (Rn)
Entrez Gene	1441 (Hs), 12986 (Mm), 298518 (Rn)
Human Protein Atlas	ENSG00000119535 (Hs)
KEGG Gene	hsa:1441 (Hs), mmu:12986 (Mm), rno:298518 (Rn)
OMIM	138971 (Hs)
Orphanet	ORPHA159476 (Hs)
Pharos	Q99062 (Hs)
UniProtKB	Q99062 (Hs), P40223 (Mm)
Wikipedia	CSF3R (Hs)

Selected 3D Structures
	Description:  Crystal Structure of the human GCSF-receptor signaling complex PDB Id:  2D9Q Resolution:  2.8Å Species:  Human References:  4

Natural/Endogenous Ligands
G-CSF {Sp: Human}

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference G-CSF {Sp: Human} Hs Agonist - - ⤷ pegfilgrastim Hs Agonist - - ⤷
Agonist Comments
The granulocyte colony-stimulating factor receptor (CSF3R) is the primary target for the approved drugs filgrastim and pegfilgrastim.

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference anumigilimab Monkey Binding 9.3 pKd 3 ⤷ pKd 9.3 (Kd 4.9x10-10 M) [3] Description: Binding of immobilised antibody to cynomolgus monkey CSF3R anumigilimab Hs Binding 8.9 pKd 3 ⤷ pKd 8.9 (Kd 1.4x10-9 M) [3] Description: Binding of immobilised antibody to hCSF3R

Immunopharmacology Comments

This nuclear receptor mediates the effects of the cytokine, colony stimulating factor 3 (CSF3). CSF3 regulates the production, differentiation, and function of granulocytes.

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Immune system development

Immuno Process:  Cytokine production & signalling

Immuno Process:  Chemotaxis & migration

Clinically-Relevant Mutations and Pathophysiology
Disease:  Atypical chronic myeloid leukemia Orphanet: ORPHA98824 References:  2
Disease:  Chronic neutrophilic leukemia Orphanet: ORPHA86829 References:  1-2
Disease:  Neutrophilia, hereditary OMIM: 162830 Orphanet: ORPHA279943
Disease:  Severe congenital neutropenia Description: Severe congenital neutropenia (SCN) is a heterogeneous disorder of hematopoiesis. The resulting subnormal neutrophil counts lead to early onset of severe bacterial infections. SCN can be caused by mutations in several genes including ELANE, GFI1, HAX1, G6PC3, VPS45, WASP and CSF3R. SCN1 is the commonest subtype and is caused by autosomal dominant inheritance of a defective ELANE gene. Synonyms: Kostmann syndrome OMIM: 202700, 617014, 610738, 613107, 612541, 615285, 300299, 616022 Role:  SCN7 is caused by mutation in the gene for the CSF3 receptor (CSF3R), also know as the granulocyte colony-stimulating factor receptor.