pegfilgrastim

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Ligands
pegfilgrastim

GtoPdb Ligand ID: 6969

Synonyms: Neulasta®

pegfilgrastim is an approved drug (FDA and EMA (2002))

Compound class: Peptide or derivative

Comment: This is a PEGylated version of recombinant human G-CSF. Pegylation increases circulating half-life. In addition to pegfilgrastim, lipegfilgrastim (Lonquex®) is a glyco-PEGylated long-acting G-CSF, that is an alternative to pegfilgrastim that is clinically approved [1].

Biosimilars:

Name	Trade name	Company	Clinical phase	Indications
pegfilgrastim-jmbd; MYL-1401H	Fulphila	Mylan	Approved (2018 FDA & EMA)	As per reference agent [2]
	Pelgraz	Accord	Approved (2018 EMA)	As per reference agent
	Pelmeg	Mundipharma (developed by Cinfa Biotech)	Approved (2018 EMA)	As per reference agent
	pegfilgrastim Mundipharma	Mundipharma	Approved (2019 EMA)	As per reference agent
pegfilgrastim-cbqv; CHS-1701	Udenyca	ERA Consulting; Coherus BioSciences	Approved (2018 FDA & EMA)	As per reference agent
USV pegfilgrastim	Grasustek	Juta Pharma	Approved (2019 EMA)	As per reference agent
pegfilgrastim-bmez; LA-EP2006	Ziextenzo	Sandoz	Approved (2018 EMA, 2019 FDA)	As per reference agent
pegfilgrastim-apgf; PF-06881894	Nyvepria	Pfizer	Approved (2020 FDA)	Indicated for neutropenia in patients undergoing cancer chemotherapy
pegfilgrastim; MSB11455	Stimufend	Fresenius Kabi	Approved (2022 EMA)	Indicated for neutropenia
pegfilgrastim-pbbk	Fylnetra	Amneal Pharmaceuticals	Approved (2022 FDA)	Indicated for neutropenia

Classification
Compound class	Peptide or derivative
Approved drug?	Yes (FDA and EMA (2002))

International Nonproprietary Names
INN number	INN
8114	pegfilgrastim

Synonyms
Neulasta®

Synonyms

Neulasta®

Database Links
Specialist databases
IMGT/mAb-DB	616
Other databases
CAS Registry No.	208265-92-3 (source: Scifinder)
ChEMBL Ligand	CHEMBL1201568
DrugBank Ligand	DB00019
GtoPdb PubChem SID	178103549
Search PubMed clinical trials	pegfilgrastim
Search PubMed titles	pegfilgrastim
Search PubMed titles/abstracts	pegfilgrastim
Wikipedia	Pegfilgrastim