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pegfilgrastim is an approved drug (FDA and EMA (2002))
Compound class: Peptide or derivative
Comment: This is a PEGylated version of recombinant human G-CSF. Pegylation increases circulating half-life. In addition to pegfilgrastim, lipegfilgrastim (Lonquex®) is a glyco-PEGylated long-acting G-CSF, that is an alternative to pegfilgrastim that is clinically approved .
1. Guariglia R, Martorelli MC, Lerose R, Telesca D, Milella MR, Musto P. (2016)
Lipegfilgrastim in the management of chemotherapy-induced neutropenia of cancer patients.
Biologics, 10: 1-8. [PMID:26858523]
2. Waller CF, Tiessen RG, Lawrence TE, Shaw A, Liu MS, Sharma R, Baczkowski M, Kothekar MA, Micales CE, Barve A et al.. (2018)
A pharmacokinetics and pharmacodynamics equivalence trial of the proposed pegfilgrastim biosimilar, MYL-1401H, versus reference pegfilgrastim.
J Cancer Res Clin Oncol, 144 (6): 1087-1095. [PMID:29671069]