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PLCγ2

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 1408

Nomenclature: PLCγ2

Family: Phosphoinositide-specific phospholipase C

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1265 16q24.1 PLCG2 phospholipase C gamma 2
Mouse - 1265 8 64.26 cM Plcg2 phospholipase C, gamma 2
Rat - 1265 19q12 Plcg2 phospholipase C, gamma 2
Previous and Unofficial Names Click here for help
PLC-IV | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | phosphoinositide phospholipase C-gamma-2 | phospholipase C, gamma 2 | phospholipase C-IV | PLCgamma2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | phospholipase C
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Cofactors Click here for help
Cofactor Species Comments Reference
Ca2+ Human
Endogenous activators (Human)
PIP3, Rac1 (RAC1, P63000), Rac2 (RAC2, P15153), Rac3 (RAC3, P60763)  [1,3,7]

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
CCT129957 Small molecule or natural product Hs Inhibition 5.5 pIC50 4
pIC50 5.5 (IC50 3x10-6 M) [4]
Description: Average IC50 (n=3)
Immunopharmacology Comments
Two structurally similar isoforms of PLCγ are expressed by mast cells (PLCγ1 and PLCγ2). Both are important enzymes in the integrated signalling pathways leading to mast cell activation [2,5], although PLCγ1 may be the predominant isoform active in human mast cells [6].
Cell Type Associations
Immuno Cell Type:  Mast cells
Cell Ontology Term:   mast cell (CL:0000097)
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
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GO:0002316 follicular B cell differentiation IEA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
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GO:0002092 positive regulation of receptor internalization IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0030183 B cell differentiation ISS
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GO:0002316 follicular B cell differentiation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 5 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0050852 T cell receptor signaling pathway ISS
GO:0050853 B cell receptor signaling pathway ISS
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes
GO:0030183 B cell differentiation ISS
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GO:0002316 follicular B cell differentiation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 7 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0030183 B cell differentiation ISS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0050852 T cell receptor signaling pathway ISS
GO:0050853 B cell receptor signaling pathway ISS
click arrow to show/hide IEA associations
GO:0002316 follicular B cell differentiation IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0032481 positive regulation of type I interferon production IEA

References

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1. Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG. (1998) Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem, 273 (8): 4465-9. [PMID:9468499]

2. Gilfillan AM, Tkaczyk C. (2006) Integrated signalling pathways for mast-cell activation. Nat Rev Immunol, 6 (3): 218-30. [PMID:16470226]

3. Piechulek T, Rehlen T, Walliser C, Vatter P, Moepps B, Gierschik P. (2005) Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases. J Biol Chem, 280 (47): 38923-31. [PMID:16172125]

4. Reynisson J, Court W, O'Neill C, Day J, Patterson L, McDonald E, Workman P, Katan M, Eccles SA. (2009) The identification of novel PLC-gamma inhibitors using virtual high throughput screening. Bioorg Med Chem, 17 (8): 3169-76. [PMID:19303309]

5. Saitoh S, Arudchandran R, Manetz TS, Zhang W, Sommers CL, Love PE, Rivera J, Samelson LE. (2000) LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity, 12 (5): 525-35. [PMID:10843385]

6. Tkaczyk C, Beaven MA, Brachman SM, Metcalfe DD, Gilfillan AM. (2003) The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase. J Biol Chem, 278 (48): 48474-84. [PMID:13129935]

7. Walliser C, Retlich M, Harris R, Everett KL, Josephs MB, Vatter P, Esposito D, Driscoll PC, Katan M, Gierschik P et al.. (2008) rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain. J Biol Chem, 283 (44): 30351-62. [PMID:18728011]

How to cite this page

Phosphoinositide-specific phospholipase C: PLCγ2. Last modified on 14/02/2017. Accessed on 08/05/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1408.