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interferon induced with helicase C domain 1

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2921

Nomenclature: interferon induced with helicase C domain 1

Abbreviated Name: MDA5

Family: RIG-I-like receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1025 2q24.2 IFIH1 interferon induced with helicase C domain 1
Mouse - 1025 2 C1.3 Ifih1 interferon induced with helicase C domain 1
Rat - 1027 3q21 Ifih1 interferon induced with helicase C domain 1
Previous and Unofficial Names Click here for help
MDA-5 | melanoma differentiation-associated gene 5
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:
Description Reaction Reference
RNA helicase; uses the energy from ATP to unwind RNA ATP + H(2)O <=> ADP + phosphate
Immunopharmacology Comments
MDA5 is an intracellualar RNA sensor. It recognizes longer double-stranded RNA sequences than RIG-1. In autoimmunity, MDA5 has been specifically linked with type I diabetes and anti-MDA5 autoantibodies can be detected in patients with certain connective tissue autoimmune conditions [1-3].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling
Physiological Consequences of Altering Gene Expression Click here for help
Conventional dendritic cells (cDCs), macrophages and fibroblasts isolated from MDA5 null mice have impaired IFN induction after RNA virus infection. Plasmacytoid DCs are unaffected by MDA5 knockout, suggesting nucleic acid sensing TLRs are more relevant in these cells.
Species:  Mouse
Tissue:  cDCs, macrophages and fibroblasts.


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1. Ahlers LR, Goodman AG. (2016) Nucleic acid sensing and innate immunity: signaling pathways controlling viral pathogenesis and autoimmunity. Curr Clin Microbiol Rep, 3 (3): 132-141. [PMID:27857881]

2. Hozumi H, Fujisawa T, Nakashima R, Johkoh T, Sumikawa H, Murakami A, Enomoto N, Inui N, Nakamura Y, Hosono Y et al.. (2016) Comprehensive assessment of myositis-specific autoantibodies in polymyositis/dermatomyositis-associated interstitial lung disease. Respir Med, 121: 91-99. [PMID:27888997]

3. Milam EC, Futran J, Franks Jr AG. (2016) Anti-MDA5 Antibody Dermatomyositis Overlap with Systemic Lupus Erythematosus: A Case Report and Review of the Literature. Open Rheumatol J, 10: 122-128. [PMID:28077979]

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