iodoaminopotentidine [Ligand Id: 1232] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL72193 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Histamine H2 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2882] [UniProtKB: P47747] | ||||||||
| ChEMBL | Histamine H2 receptor antagonistic activity at a concentration of 1 uM on the isolated guinea pig right atrium. | F | 7.56 | pKd | 27.54 | nM | Kd | J Med Chem (1992) 35: 2231-2238 [PMID:1613748] |
| ChEMBL | Inhibition of [125I]APT binding to histamine H2 receptor in guinea pig cerebral membranes. | B | 9.15 | pKi | 0.71 | nM | Ki | J Med Chem (1992) 35: 2231-2238 [PMID:1613748] |
| H2 receptor in Rat [GtoPdb: 263] [UniProtKB: P25102] | ||||||||
| GtoPdb | - | - | 9.2 | pKi | - | - | - | Br J Pharmacol (1997) 122: 867-74 [PMID:9384502] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
