propylpyrazoletriol [Ligand Id: 2819] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL441282 (Propylpyrazoletriol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372] | ||||||||
| GtoPdb | - | - | 9.64 | pKi | - | - | - |
J Med Chem (2000) 43: 4934-47 [PMID:11150164]; Endocrinology (2000) 141: 3534-45 [PMID:11014206] |
| ChEMBL | Activation of ERalpha in human MCF7/2a cells by luciferase reporter gene assay relative to untreated control | B | 8.52 | pEC50 | 3 | nM | EC50 | J Med Chem (2012) 55: 9607-9618 [PMID:23043242] |
| ChEMBL | Activation of human ERalpha expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated control | B | 10 | pEC50 | 0.1 | nM | EC50 | J Med Chem (2012) 55: 9607-9618 [PMID:23043242] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.2 | pIC50 | 6309.57 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
