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ChEMBL ligand: CHEMBL441282 (Propylpyrazoletriol) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372] | ||||||||
GtoPdb | - | - | 9.64 | pKi | - | - | - |
J Med Chem (2000) 43: 4934-47 [PMID:11150164]; Endocrinology (2000) 141: 3534-45 [PMID:11014206] |
ChEMBL | Activation of ERalpha in human MCF7/2a cells by luciferase reporter gene assay relative to untreated control | B | 8.52 | pEC50 | 3 | nM | EC50 | J. Med. Chem. (2012) 55: 9607-9618 [PMID:23043242] |
ChEMBL | Activation of human ERalpha expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated control | B | 10 | pEC50 | 0.1 | nM | EC50 | J. Med. Chem. (2012) 55: 9607-9618 [PMID:23043242] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.2 | pIC50 | 6309.57 | nM | IC50 | Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]