propylpyrazoletriol [Ligand Id: 2819] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL441282 (Propylpyrazoletriol)
  • Estrogen receptor-α/Estrogen receptor alpha in Human [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
GtoPdb - - 9.64 pKi - - - J Med Chem (2000) 43: 4934-47 [PMID:11150164];
Endocrinology (2000) 141: 3534-45 [PMID:11014206]
ChEMBL Activation of ERalpha in human MCF7/2a cells by luciferase reporter gene assay relative to untreated control B 8.52 pEC50 3 nM EC50 J. Med. Chem. (2012) 55: 9607-9618 [PMID:23043242]
ChEMBL Activation of human ERalpha expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated control B 10 pEC50 0.1 nM EC50 J. Med. Chem. (2012) 55: 9607-9618 [PMID:23043242]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay F 5.2 pIC50 6309.57 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]