deferiprone [Ligand Id: 7456] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL70927 (APO-066, APO-66, CP-20, CP20, Deferipron, Deferiprona, Deferiprone, DN-180-01-AF, DN-18001AF, Ferriprox, L-1, L1, NSC-758880, PL-1, PL1) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Deoxyhypusine hydroxylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523441] [UniProtKB: Q9BU89] | ||||||||
| ChEMBL | Inhibition of DOHH (unknown origin) | B | 5.3 | pIC50 | 5000 | nM | IC50 | Eur J Med Chem (2019) 165: 172-197 [PMID:30684796] |
| lysine demethylase 2A/Lysine-specific demethylase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1938210] [GtoPdb: 2671] [UniProtKB: Q9Y2K7] | ||||||||
| ChEMBL | Inhibition of KDM2A (unknown origin) | B | 5.17 | pIC50 | 6800 | nM | IC50 | Eur J Med Chem (2022) 231: 114143-114143 [PMID:35101649] |
| lysine demethylase 2B/Lysine-specific demethylase 2B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3779760] [GtoPdb: 2672] [UniProtKB: Q8NHM5] | ||||||||
| ChEMBL | Inhibition of KDM2B (unknown origin) | B | 5.09 | pIC50 | 8100 | nM | IC50 | Eur J Med Chem (2022) 231: 114143-114143 [PMID:35101649] |
| lysine demethylase 4A/Lysine-specific demethylase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5896] [GtoPdb: 2675] [UniProtKB: O75164] | ||||||||
| ChEMBL | Inhibition of KDM4A (unknown origin) measured by LANCEUltra assay | B | 5.48 | pIC50 | 3330 | nM | IC50 | J Med Chem (2022) 65: 9564-9579 [PMID:35838529] |
| ChEMBL | Inhibition of KDM4A (unknown origin) measured by formaldehyde dehydrogenase (FDH)-coupled fluorescence assay | B | 5.49 | pIC50 | 3220 | nM | IC50 | J Med Chem (2022) 65: 9564-9579 [PMID:35838529] |
| lysine demethylase 5C/Lysine-specific demethylase 5C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2163176] [GtoPdb: 2682] [UniProtKB: P41229] | ||||||||
| ChEMBL | Inhibition of KDM5C (unknown origin) | B | 5.25 | pIC50 | 5600 | nM | IC50 | Eur J Med Chem (2022) 231: 114143-114143 [PMID:35101649] |
| lysine demethylase 6A/Lysine-specific demethylase 6A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069164] [GtoPdb: 2684] [UniProtKB: O15550] | ||||||||
| ChEMBL | Inhibition of KDM6A (unknown origin) | B | 5.38 | pIC50 | 4200 | nM | IC50 | Eur J Med Chem (2022) 231: 114143-114143 [PMID:35101649] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum TM267TR after 24 hrs by [3H]hypoxanthine | F | 4.17 | pIC50 | 67500 | nM | IC50 | Eur J Med Chem (2008) 43: 1035-1047 [PMID:17869385] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
