deferiprone [Ligand Id: 7456] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL70927 (APO-066, APO-66, CP-20, CP20, Deferipron, Deferiprone, DN-180-01-AF, DN-18001AF, Ferriprox, L-1, L1, NSC-758880, PL-1, PL1) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Deoxyhypusine hydroxylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523441] [UniProtKB: Q9BU89] | ||||||||
| ChEMBL | Inhibition of DOHH (unknown origin) | B | 5.3 | pIC50 | 5000 | nM | IC50 | Eur J Med Chem (2019) 165: 172-197 [PMID:30684796] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum TM267TR after 24 hrs by [3H]hypoxanthine | F | 4.17 | pIC50 | 67500 | nM | IC50 | Eur J Med Chem (2008) 43: 1035-1047 [PMID:17869385] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
