deferiprone [Ligand Id: 7456] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL70927 (APO-066, APO-66, CP20, CP-20, Deferipron, Deferiprone, DN-18001AF, DN-180-01-AF, Ferriprox, L1, L-1, NSC-758880, PL1, PL-1)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Deoxyhypusine hydroxylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523441] [UniProtKB: Q9BU89]
ChEMBL Inhibition of DOHH (unknown origin) B 5.3 pIC50 5000 nM IC50 Eur J Med Chem (2019) 165: 172-197 [PMID:30684796]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum TM267TR after 24 hrs by [3H]hypoxanthine F 4.17 pIC50 67500 nM IC50 Eur. J. Med. Chem. (2008) 43: 1035-1047 [PMID:17869385]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]