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lysine demethylase 2A

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Target not currently curated in GtoImmuPdb

Target id: 2671

Nomenclature: lysine demethylase 2A

Family: 1.14.11.- Histone demethylases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1162 11q13.2 KDM2A lysine demethylase 2A
Mouse - 1161 19 A Kdm2a lysine (K)-specific demethylase 2A
Rat - 1161 1q42 Kdm2a lysine demethylase 2A
Previous and Unofficial Names Click here for help
FBXL11 | lysine (K)-specific demethylase 2A
Database Links Click here for help
Alphafold Q9Y2K7 (Hs), P59997 (Mm)
CATH/Gene3D 3.30.40.10, 3.80.10.10
ChEMBL Target CHEMBL1938210 (Hs)
Ensembl Gene ENSG00000173120 (Hs), ENSMUSG00000054611 (Mm), ENSRNOG00000019145 (Rn)
Entrez Gene 22992 (Hs), 225876 (Mm), 361700 (Rn)
Human Protein Atlas ENSG00000173120 (Hs)
KEGG Gene hsa:22992 (Hs), mmu:225876 (Mm), rno:361700 (Rn)
OMIM 605657 (Hs)
Pharos Q9Y2K7 (Hs)
RefSeq Nucleotide NM_012308 (Hs), NM_001001984 (Mm), NM_001108515 (Rn)
RefSeq Protein NP_036440 (Hs), NP_001001984 (Mm), NP_001101985 (Rn)
UniProtKB Q9Y2K7 (Hs), P59997 (Mm)
Wikipedia KDM2A (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
IOX2 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.3 pIC50 1
⤷ pIC50 7.3 (IC50 5.2x10-8 M) [1]
daminozide Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 5.8 pIC50 2
⤷ pIC50 5.8 (IC50 1.5x10-6 M) [2]
Immuno Process Associations
Immuno Process:  Cellular signalling

References

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1. Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian YM, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A et al.. (2013) Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol, 8 (7): 1488-96. [PMID:23683440]

2. Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T et al.. (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem, 55 (14): 6639-43. [PMID:22724510]

How to cite this page

1.14.11.- Histone demethylases: lysine demethylase 2A. Last modified on 30/03/2016. Accessed on 07/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2671.