oridonin [Ligand Id: 13088] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1164920 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AKT serine/threonine kinase 1 in Human [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
| GtoPdb | - | - | 5.08 | pIC50 | 8400 | nM | IC50 | Mol Cancer Ther (2018) 17: 1540-1553 [PMID:29695636] |
| AKT serine/threonine kinase 2 in Human [GtoPdb: 1480] [UniProtKB: P31751] | ||||||||
| GtoPdb | - | - | 5.05 | pIC50 | 8900 | nM | IC50 | Mol Cancer Ther (2018) 17: 1540-1553 [PMID:29695636] |
| NLRP3 in Human [GtoPdb: 1770] [UniProtKB: Q96P20] | ||||||||
| GtoPdb | Equilibrium dissociation constant (KD) for oridonin binding to purified GFP-NLRP3. | - | 7.28 | pKd | 52.5 | nM | Kd | Nat Commun (2018) 9: 2550 [PMID:29959312] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
