vidupiprant [Ligand Id: 10169] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1951575 (AMG 853, AMG-853, Vidupiprant) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Calpain 1 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4062] [UniProtKB: P35750] | ||||||||
| ChEMBL | Inhibition of porcine Calpain-1 active site domain using (H2NeK(-FAM)-EVYGMMK(DABCYL)eOH) substrate by FRET assay | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2018) 157: 1264-1275 [PMID:30195237] |
| ChEMBL | Inhibition of full length porcine Calpain-1 complex using (H2NeK(-FAM)-EVYGMMK(DABCYL)eOH) substrate by FRET assay | B | 5.12 | pIC50 | 7500 | nM | IC50 | Eur J Med Chem (2018) 157: 1264-1275 [PMID:30195237] |
| DP2 receptor/G protein-coupled receptor 44 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4] | ||||||||
| ChEMBL | Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 50% human plasma | B | 8.1 | pIC50 | 8 | nM | IC50 | ACS Med Chem Lett (2011) 2: 326-330 [PMID:24900313] |
| GtoPdb | - | - | 8.52 | pIC50 | 3 | nM | IC50 | ACS Med Chem Lett (2011) 2: 326-30 [PMID:24900313] |
| ChEMBL | Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin | B | 8.52 | pIC50 | 3 | nM | IC50 | ACS Med Chem Lett (2011) 2: 326-330 [PMID:24900313] |
| DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
| ChEMBL | Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 50% human plasma | B | 7.46 | pIC50 | 35 | nM | IC50 | ACS Med Chem Lett (2011) 2: 326-330 [PMID:24900313] |
| ChEMBL | Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin | B | 8.4 | pIC50 | 4 | nM | IC50 | ACS Med Chem Lett (2011) 2: 326-330 [PMID:24900313] |
| GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | ACS Med Chem Lett (2011) 2: 326-30 [PMID:24900313] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
