vidupiprant [Ligand Id: 10169] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1951575 (AMG 853, AMG-853, AMG853, Vidupiprant) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Calpain 1 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4062] [UniProtKB: P35750] | ||||||||
| ChEMBL | Inhibition of porcine Calpain-1 active site domain using (H2NeK(-FAM)-EVYGMMK(DABCYL)eOH) substrate by FRET assay | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2018) 157: 1264-1275 [PMID:30195237] |
| ChEMBL | Inhibition of full length porcine Calpain-1 complex using (H2NeK(-FAM)-EVYGMMK(DABCYL)eOH) substrate by FRET assay | B | 5.12 | pIC50 | 7500 | nM | IC50 | Eur J Med Chem (2018) 157: 1264-1275 [PMID:30195237] |
| DP2 receptor/G protein-coupled receptor 44 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4] | ||||||||
| ChEMBL | Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 50% human plasma | B | 8.1 | pIC50 | 8 | nM | IC50 | ACS Med Chem Lett (2011) 2: 326-330 [PMID:24900313] |
| GtoPdb | - | - | 8.52 | pIC50 | 3 | nM | IC50 | ACS Med Chem Lett (2011) 2: 326-30 [PMID:24900313] |
| ChEMBL | Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin | B | 8.52 | pIC50 | 3 | nM | IC50 | ACS Med Chem Lett (2011) 2: 326-330 [PMID:24900313] |
| DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
| ChEMBL | Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 50% human plasma | B | 7.46 | pIC50 | 35 | nM | IC50 | ACS Med Chem Lett (2011) 2: 326-330 [PMID:24900313] |
| ChEMBL | Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin | B | 8.4 | pIC50 | 4 | nM | IC50 | ACS Med Chem Lett (2011) 2: 326-330 [PMID:24900313] |
| GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | ACS Med Chem Lett (2011) 2: 326-30 [PMID:24900313] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
