bilobalide | Ligand Activity Charts | IUPHAR/BPS Guide to PHARMACOLOGY

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Ligand Activity Charts

bilobalide [Ligand Id: 2366] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1318117
5-HT₃AB in Human [GtoPdb: 378] There should be some charts here, you may need to enable JavaScript!
5-HT₃A in Human [GtoPdb: 379] There should be some charts here, you may need to enable JavaScript!
glycine receptor α1 subunit in Human [GtoPdb: 423] [UniProtKB: P23415] There should be some charts here, you may need to enable JavaScript!
glycine receptor α2 subunit in Human [GtoPdb: 424] [UniProtKB: P23416] There should be some charts here, you may need to enable JavaScript!
glycine receptor β subunit in Human [GtoPdb: 427] [UniProtKB: P48167] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-HT₃AB in Human [GtoPdb: 378]
GtoPdb	-	-	2.51	pIC50	3100000	nM	IC50	Neuropharmacology (2011) 60: 488-95 [PMID:21059362]
5-HT₃A in Human [GtoPdb: 379]
GtoPdb	-	-	3.33	pIC50	470000	nM	IC50	Mol Pharmacol (2011) 80: 183-90 [PMID:21505038]
glycine receptor α1 subunit in Human [GtoPdb: 423] [UniProtKB: P23415]
GtoPdb	-	-	4.7	pIC50	20000	nM	IC50
glycine receptor α2 subunit in Human [GtoPdb: 424] [UniProtKB: P23416]
GtoPdb	-	-	5.1	pIC50	8000	nM	IC50
glycine receptor β subunit in Human [GtoPdb: 427] [UniProtKB: P48167]
GtoPdb	-	-	3.7	pIC50	204000	nM	IC50
GtoPdb	-	-	4.3	pIC50	50000	nM	IC50

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]