tafluprost   Click here for help

GtoPdb Ligand ID: 7451

Synonyms: AFP-168 | MK-2452 | Taflotan®
Approved drug
tafluprost is an approved drug (FDA (2012))
Compound class: Synthetic organic
Comment: Tafluprost is a prostaglandin analogue.
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View more information in the IUPHAR Pharmacology Education Project: tafluprost

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 75.99
Molecular weight 452.24
XLogP 4.74
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC(OC(=O)CCCC=CCC1C(O)CC(C1C=CC(COc1ccccc1)(F)F)O)C
Isomeric SMILES CC(OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/C(COc1ccccc1)(F)F)O)C
InChI InChI=1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3-,15-14+/t20-,21-,22+,23-/m1/s1
InChI Key WSNODXPBBALQOF-VEJSHDCNSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2012))
Is prodrug? Yes
Active form tafluprost acid
IUPAC Name Click here for help
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-difluoro-4-(phenoxy)but-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate
International Nonproprietary Names Click here for help
INN number INN
8374 tafluprost
Synonyms Click here for help
AFP-168 | MK-2452 | Taflotan®
Database Links Click here for help
Specialist databases
GPCRdb Ligand tafluprost
Other databases
CAS Registry No. 209860-87-7
ChEBI CHEBI:66899
ChEMBL Ligand CHEMBL1963683
DrugBank Ligand DB08819
DrugCentral Ligand 4229
GtoPdb PubChem SID 187051754
PubChem CID 9868491
Search Google for chemical match using the InChIKey WSNODXPBBALQOF-VEJSHDCNSA-N
Search Google for chemicals with the same backbone WSNODXPBBALQOF
Search PubMed clinical trials tafluprost
Search PubMed titles tafluprost
Search PubMed titles/abstracts tafluprost
UniChem Compound Search for chemical match using the InChIKey WSNODXPBBALQOF-VEJSHDCNSA-N
UniChem Connectivity Search for chemical match using the InChIKey WSNODXPBBALQOF-VEJSHDCNSA-N
Wikipedia Tafluprost