compound 11 [PMID: 16413183] [Ligand Id: 8493] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL206454
  • kallikrein B1/Plasma kallikrein in Human [ChEMBL: CHEMBL2000] [GtoPdb: 2379] [UniProtKB: P03952]
  • 9.3
1 CHEMBL206454_lig_chart_1 Plasma kallikrein Human
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  • coagulation factor VII in Human [GtoPdb: 2363] [UniProtKB: P08709]
  • This target only has 1 pki data point
  • 7
2 CHEMBL206454_lig_chart_2 coagulation factor VII Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
kallikrein B1/Plasma kallikrein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2000] [GtoPdb: 2379] [UniProtKB: P03952]
GtoPdb - - 9.3 pKi 0.5 nM Ki Bioorg Med Chem Lett (2006) 16: 2034-6 [PMID:16413183]
ChEMBL Binding affinity to plasma kallikrein B 9.3 pKi 0.5 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 2034-2036 [PMID:16413183]
coagulation factor VII in Human [GtoPdb: 2363] [UniProtKB: P08709]
GtoPdb Ki calculated from fold selectivity for KLKB1. - 7 pKi ~100 nM Ki Bioorg Med Chem Lett (2006) 16: 2034-6 [PMID:16413183]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]