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coagulation factor VII

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Target not currently curated in GtoImmuPdb

Target id: 2363

Nomenclature: coagulation factor VII

Family: S1: Chymotrypsin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 466 13q34 F7 coagulation factor VII
Mouse - 446 8 5.73 cM F7 coagulation factor VII
Rat - 446 16q12.5 F7 coagulation factor VII
Previous and Unofficial Names Click here for help
factor VII | Cf7 | eptacog alfa | FVII | serum prothrombin conversion accelerator | coagulation factor VII (serum prothrombin conversion accelerator)
Database Links Click here for help
Specialist databases
MEROPS S01.215 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.21.21

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 1 [PMID: 16650987] Small molecule or natural product Hs Inhibition 9.0 pKi 1
pKi 9.0 (Ki 1x10-9 M) [1]
compound 11 [PMID: 16413183] Small molecule or natural product Click here for species-specific activity table Hs Inhibition ~7.0 pKi 2
pKi ~7.0 (Ki ~1x10-7 M) [2]
Description: Ki calculated from fold selectivity for KLKB1.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0002690 positive regulation of leukocyte chemotaxis IDA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0002690 positive regulation of leukocyte chemotaxis IDA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0002690 positive regulation of leukocyte chemotaxis IDA
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Factor VII deficiency
Disease Ontology: DOID:2215
OMIM: 227500
Orphanet: ORPHA327

References

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1. Vijaykumar D, Rai R, Shaghafi M, Ton T, Torkelson S, Leahy EM, Riggs JR, Hu H, Sprengeler PA, Shrader WD et al.. (2006) Efforts toward oral bioavailability in factor VIIa inhibitors. Bioorg Med Chem Lett, 16 (14): 3829-32. [PMID:16650987]

2. Young WB, Rai R, Shrader WD, Burgess-Henry J, Hu H, Elrod KC, Sprengeler PA, Katz BA, Sukbuntherng J, Mordenti J. (2006) Small molecule inhibitors of plasma kallikrein. Bioorg Med Chem Lett, 16 (7): 2034-6. [PMID:16413183]

How to cite this page

S1: Chymotrypsin: coagulation factor VII. Last modified on 29/01/2016. Accessed on 20/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2363.