coagulation factor VII | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

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coagulation factor VII

Target not currently curated in GtoImmuPdb

Target id: 2363

Nomenclature: coagulation factor VII

Family: S1: Chymotrypsin

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 466 13q34 F7 coagulation factor VII
Mouse - 446 8 A1.1 F7 coagulation factor VII
Rat - 446 16q12.5 F7 coagulation factor VII
Previous and Unofficial Names
factor VII | Cf7 | eptacog alfa | FVII | serum prothrombin conversion accelerator | coagulation factor VII (serum prothrombin conversion accelerator)
Database Links
Specialist databases
MEROPS S01.215 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 1 [PMID: 16650987] Hs Inhibition 9.0 pKi 1
pKi 9.0 (Ki 1x10-9 M) [1]
compound 11 [PMID: 16413183] Hs Inhibition ~7.0 pKi 2
pKi ~7.0 (Ki ~1x10-7 M) [2]
Description: Ki calculated from fold selectivity for KLKB1.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Factor VII deficiency
Disease Ontology: DOID:2215
OMIM: 227500
Orphanet: ORPHA327


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1. Vijaykumar D, Rai R, Shaghafi M, Ton T, Torkelson S, Leahy EM, Riggs JR, Hu H, Sprengeler PA, Shrader WD et al.. (2006) Efforts toward oral bioavailability in factor VIIa inhibitors. Bioorg. Med. Chem. Lett., 16 (14): 3829-32. [PMID:16650987]

2. Young WB, Rai R, Shrader WD, Burgess-Henry J, Hu H, Elrod KC, Sprengeler PA, Katz BA, Sukbuntherng J, Mordenti J. (2006) Small molecule inhibitors of plasma kallikrein. Bioorg. Med. Chem. Lett., 16 (7): 2034-6. [PMID:16413183]

How to cite this page

S1: Chymotrypsin: coagulation factor VII. Last modified on 29/01/2016. Accessed on 20/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY,