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- Home
- Targets
- Enzymes
- Peptidases and proteinases
- PA: Serine (S) Peptidases
- S1: Chymotrypsin
S1: Chymotrypsin C
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Enzymes
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acrosin
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cathepsin G
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chymase 1
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chymotrypsin C
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chymotrypsin like
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chymotrypsin like elastase 1
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chymotrypsin like elastase 2A
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chymotrypsinogen B1 Show summary »« Hide summary
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complement C1r
C
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complement C1s
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complement factor B
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coagulation factor II, thrombin / prothrombin
C
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coagulation factor VII
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coagulation factor IX
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coagulation factor X
C
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coagulation factor XI
C
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coagulation factor XII
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elastase, neutrophil expressed
C
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granzyme A
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granzyme B
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granzyme K
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HtrA serine peptidase 1 Show summary »« Hide summary
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kallikrein B1
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kallikrein 1
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kallikrein related peptidase 2
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kallikrein related peptidase 3
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kallikrein related peptidase 4
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kallikrein related peptidase 5
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kallikrein related peptidase 6
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kallikrein related peptidase 7
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kallikrein related peptidase 8
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kallikrein related peptidase 14
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plasminogen
C
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plasminogen activator, tissue type
C
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plasminogen activator, urokinase
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serine protease 1
C
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serine protease 2
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serine protease 3
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serine protease 8
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protein C, inactivator of coagulation factors Va and VIIIa
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proteinase 3
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ST14 transmembrane serine protease matriptase
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transmembrane serine protease 2
C
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transmembrane serine protease 6
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transmembrane serine protease 11D
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transmembrane serine protease 15 Show summary »« Hide summary
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tryptase alpha/beta 1
C
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tryptase gamma 1
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References
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3. Coste T, Hervé D, Neau JP, Jouvent E, Ba F, Bergametti F, Lamy M, Cogez J, Derache N, Schneckenburger R et al.. (2021) Heterozygous HTRA1 nonsense or frameshift mutations are pathogenic. Brain, 144 (9): 2616-2624. [PMID:34270682]
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12. He F, Li X, Cai S, Lu L, Zhang T, Yang M, Fan N, Wang X, Liu X. (2022) Polymorphism rs11200638 enhanced HtrA1 responsiveness and expression are associated with age-related macular degeneration. Eye (Lond), 36 (8): 1631-1638. [PMID:34326497]
13. Ieko M, Tarumi T, Takeda M, Naito S, Nakabayashi T, Koike T. (2004) Synthetic selective inhibitors of coagulation factor Xa strongly inhibit thrombin generation without affecting initial thrombin forming time necessary for platelet activation in hemostasis. J Thromb Haemost, 2 (4): 612-8. [PMID:15102016]
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16. Kawashima I, Tani T, Shimoda K, Takiguchi Y. (1987) Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. DNA, 6 (2): 163-72. [PMID:3646943]
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18. Kotian PL, Babu YS, Wu M, Chintareddy VR, Kumar VS, Zhang W. (2015) Human plasma kallikrein inhibitors. Patent number: WO2015134998A1. Assignee: Biocryst Pharmaceuticals. Priority date: 07/03/2014. Publication date: 11/09/2015.
19. Lin MK, Yang J, Hsu CW, Gore A, Bassuk AG, Brown LM, Colligan R, Sengillo JD, Mahajan VB, Tsang SH. (2018) HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1. Aging Cell, 17 (4): e12710. [PMID:29730901]
20. Liverton NJ, Carroll SS, Dimuzio J, Fandozzi C, Graham DJ, Hazuda D, Holloway MK, Ludmerer SW, McCauley JA, McIntyre CJ et al.. (2010) MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease. Antimicrob Agents Chemother, 54 (1): 305-11. [PMID:19841155]
21. Longhurst HJ, Lindsay K, Petersen RS, Fijen LM, Gurugama P, Maag D, Butler JS, Shah MY, Golden A, Xu Y et al.. (2024) CRISPR-Cas9 In Vivo Gene Editing of KLKB1 for Hereditary Angioedema. N Engl J Med, 390 (5): 432-441. [PMID:38294975]
22. Mori S, Itoh Y, Shinohata R, Sendo T, Oishi R, Nishibori M. (2003) Nafamostat mesilate is an extremely potent inhibitor of human tryptase. J Pharmacol Sci, 92 (4): 420-3. [PMID:12939527]
23. Muthusamy K, Ferrer A, Klee EW, Wierenga KJ, Gavrilova RH. (2021) Clinicoradiographic and genetic features of cerebral small vessel disease indicate variability in mode of inheritance for monoallelic HTRA1 variants. Mol Genet Genomic Med, 9 (10): e1799. [PMID:34510819]
24. Pakkala M, Hekim C, Soininen P, Leinonen J, Koistinen H, Weisell J, Stenman UH, Vepsäläinen J, Närvänen A. (2007) Activity and stability of human kallikrein-2-specific linear and cyclic peptide inhibitors. J Pept Sci, 13 (5): 348-53. [PMID:17436344]
25. Perzborn E, Strassburger J, Wilmen A, Pohlmann J, Roehrig S, Schlemmer KH, Straub A. (2005) In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939--an oral, direct Factor Xa inhibitor. J Thromb Haemost, 3 (3): 514-21. [PMID:15748242]
26. Pinto DJ, Smallheer JM, Cheney DL, Knabb RM, Wexler RR. (2010) Factor Xa inhibitors: next-generation antithrombotic agents. J Med Chem, 53 (17): 6243-74. [PMID:20503967]
27. Sasaki M, Miyahisa I, Itono S, Yashiro H, Hiyoshi H, Tsuchimori K, Hamagami KI, Moritoh Y, Watanabe M, Tohyama K et al.. (2019) Discovery and characterization of a small-molecule enteropeptidase inhibitor, SCO-792. Pharmacol Res Perspect, 7 (5): e00517. [PMID:31508234]
28. Schaefer M, Buchmueller A, Dittmer F, Straßburger J, Wilmen A. (2019) Allosteric Inhibition as a New Mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated Form of Coagulation Factor XI. J Mol Biol, 431 (24): 4817-4833. [PMID:31655039]
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33. Stevens T, Ekholm K, Gränse M, Lindahl M, Kozma V, Jungar C, Ottosson T, Falk-Håkansson H, Churg A, Wright JL et al.. (2011) AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. J Pharmacol Exp Ther, 339 (1): 313-20. [PMID:21791628]
34. Stone GW, McLaurin BT, Cox DA, Bertrand ME, Lincoff AM, Moses JW, White HD, Pocock SJ, Ware JH, Feit F et al.. (2006) Bivalirudin for patients with acute coronary syndromes. N Engl J Med, 355 (21): 2203-16. [PMID:17124018]
35. Sun W, Zhang X, Cummings MD, Albarazanji K, Wu J, Wang M, Alexander R, Zhu B, Zhang Y, Leonard J et al.. (2020) Targeting Enteropeptidase with Reversible Covalent Inhibitors To Achieve Metabolic Benefits. J Pharmacol Exp Ther, 375 (3): 510-521. [PMID:33033171]
36. Tan X, Soualmia F, Furio L, Renard JF, Kempen I, Qin L, Pagano M, Pirotte B, El Amri C, Hovnanian A et al.. (2015) Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J Med Chem, 58 (2): 598-612. [PMID:25489658]
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38. Wang Y, Nie G. (2021) Overview of Human HtrA Family Proteases and Their Distinctive Physiological Roles and Unique Involvement in Diseases, Especially Cancer and Pregnancy Complications. Int J Mol Sci, 22 (19). DOI: 10.3390/ijms221910756 [PMID:34639128]
39. Warkentin TE, Greinacher A, Craven S, Dewar L, Sheppard JA, Ofosu FA. (2005) Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation. Thromb Haemost, 94 (5): 958-64. [PMID:16363236]
40. Wienen W, Stassen J-M, Priepke H, Ries UJ, Hauel N. (2007) In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate. Thrombosis and Haemostasis, 98 (01): 155-162. DOI: DOI: 10.1160/TH07-03-0183
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44. Yashiro H, Hamagami K, Hiyoshi H, Sugama J, Tsuchimori K, Yamaguchi F, Moritoh Y, Sasaki M, Maekawa T, Yamada Y et al.. (2019) SCO-792, an enteropeptidase inhibitor, improves disease status of diabetes and obesity in mice. Diabetes Obes Metab, 21 (10): 2228-2239. [PMID:31144422]
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How to cite this family page
Database page citation:
S1: Chymotrypsin. Accessed on 16/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=751.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.
