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kallikrein related peptidase 5

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Target not currently curated in GtoImmuPdb

Target id: 2375

Nomenclature: kallikrein related peptidase 5

Family: S1: Chymotrypsin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 293 19q13.41 KLK5 kallikrein related peptidase 5
Mouse - 293 7 B4 Klk5 kallikrein related-peptidase 5
Rat - - q22 Klk5 kallikrein related-peptidase 5
Previous and Unofficial Names Click here for help
kallikrein 5 | kallikrein-5 | KLK-L2 | SCTE | kallikrein-related peptidase 5
Database Links Click here for help
Specialist databases
MEROPS S01.017 (Hs)
Other databases
Alphafold Q9Y337 (Hs)
BRENDA 3.4.21.-
ChEMBL Target CHEMBL4447 (Hs)
Ensembl Gene ENSG00000167754 (Hs), ENSMUSG00000074155 (Mm), ENSRNOG00000018831 (Rn)
Entrez Gene 25818 (Hs), 68668 (Mm), 690603 (Rn)
Human Protein Atlas ENSG00000167754 (Hs)
KEGG Enzyme 3.4.21.-
KEGG Gene hsa:25818 (Hs), mmu:68668 (Mm), rno:690603 (Rn)
OMIM 605643 (Hs)
Pharos Q9Y337 (Hs)
RefSeq Nucleotide NM_001077492 (Hs), NM_001077491 (Hs), NM_012427 (Hs), NM_026806 (Mm)
RefSeq Protein NP_001070960 (Hs), NP_036559 (Hs), NP_001070959 (Hs), NP_081082 (Mm)
UniProtKB Q9Y337 (Hs)
Wikipedia KLK5 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3 [PMID: 23849879] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.6 pIC50 1
⤷ pIC50 6.6 (IC50 2.7x10-7 M) [1]
compound 4d [PMID: 25489658] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.0 pIC50 2
⤷ pIC50 6.0 (IC50 9.2x10-7 M) [2]
Immuno Process Associations
Immuno Process:  Immune regulation

References

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1. Tan X, Furio L, Reboud-Ravaux M, Villoutreix BO, Hovnanian A, El Amri C. (2013) 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg Med Chem Lett, 23 (16): 4547-51. [PMID:23849879]

2. Tan X, Soualmia F, Furio L, Renard JF, Kempen I, Qin L, Pagano M, Pirotte B, El Amri C, Hovnanian A et al.. (2015) Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J Med Chem, 58 (2): 598-612. [PMID:25489658]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 5. Last modified on 29/01/2016. Accessed on 23/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2375.